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Page 1
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease.
Selvarajan I, Toropainen A, Garske KM, López Rodríguez M, Ko A, Miao Z, Kaminska D, Õunap K, Örd T, Ravindran A, Liu OH, Moreau PR, Jawahar Deen A, Männistö V, Pan C, Levonen AL, Lusis AJ, Heikkinen S, Romanoski CE, Pihlajamäki J, Pajukanta P, Kaikkonen MU. Selvarajan I, et al. Am J Hum Genet. 2021 Mar 4;108(3):411-430. doi: 10.1016/j.ajhg.2021.02.006. Epub 2021 Feb 23. Am J Hum Genet. 2021. PMID: 33626337 Free PMC article.
Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits.
Stolze LK, Conklin AC, Whalen MB, López Rodríguez M, Õunap K, Selvarajan I, Toropainen A, Örd T, Li J, Eshghi A, Solomon AE, Fang Y, Kaikkonen MU, Romanoski CE. Stolze LK, et al. Among authors: selvarajan i. Am J Hum Genet. 2020 Jun 4;106(6):748-763. doi: 10.1016/j.ajhg.2020.04.008. Epub 2020 May 21. Am J Hum Genet. 2020. PMID: 32442411 Free PMC article.
Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci.
Örd T, Õunap K, Stolze LK, Aherrahrou R, Nurminen V, Toropainen A, Selvarajan I, Lönnberg T, Aavik E, Ylä-Herttuala S, Civelek M, Romanoski CE, Kaikkonen MU. Örd T, et al. Among authors: selvarajan i. Circ Res. 2021 Jul 9;129(2):240-258. doi: 10.1161/CIRCRESAHA.121.318971. Epub 2021 May 24. Circ Res. 2021. PMID: 34024118 Free PMC article.
Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.
Selvarajan I, Kiema M, Huang RT, Li J, Zhu J, Pölönen P, Örd T, Õunap K, Godiwala M, Golebiewski AK, Ravindran A, Mäklin K, Toropainen A, Stolze LK, Arce M, Magnusson PU, White S, Romanoski CE, Heinäniemi M, Laakkonen JP, Fang Y, Kaikkonen MU. Selvarajan I, et al. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1330-1345. doi: 10.1161/ATVBAHA.123.318964. Epub 2024 Apr 11. Arterioscler Thromb Vasc Biol. 2024. PMID: 38602103 Free article.
Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis.
Ravindran A, Holappa L, Niskanen H, Skovorodkin I, Kaisto S, Beter M, Kiema M, Selvarajan I, Nurminen V, Aavik E, Aherrahrou R, Pasonen-Seppänen S, Fortino V, Laakkonen JP, Ylä-Herttuala S, Vainio S, Örd T, Kaikkonen MU. Ravindran A, et al. Among authors: selvarajan i. Cardiovasc Res. 2024 Jul 2;120(8):869-882. doi: 10.1093/cvr/cvae028. Cardiovasc Res. 2024. PMID: 38289873 Free PMC article.
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells.
Deen AJ, Adinolfi S, Härkönen J, Patinen T, Liu X, Laitinen T, Takabe P, Kainulainen K, Pasonen-Seppänen S, Gawriyski LM, Arasu UT, Selvarajan I, Mäkinen P, Laitinen H, Kansanen E, Kaikkonen MU, Poso A, Varjosalo M, Levonen AL. Deen AJ, et al. Among authors: selvarajan i. Redox Biol. 2024 Feb;69:103031. doi: 10.1016/j.redox.2024.103031. Epub 2024 Jan 4. Redox Biol. 2024. PMID: 38184997 Free PMC article.
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease.
Darci-Maher N, Alvarez M, Arasu UT, Selvarajan I, Lee SHT, Pan DZ, Miao Z, Das SS, Kaminska D, Örd T, Benhammou JN, Wabitsch M, Pisegna JR, Männistö V, Pietiläinen KH, Laakso M, Sinsheimer JS, Kaikkonen MU, Pihlajamäki J, Pajukanta P. Darci-Maher N, et al. Among authors: selvarajan i. EBioMedicine. 2023 Jun;92:104620. doi: 10.1016/j.ebiom.2023.104620. Epub 2023 May 22. EBioMedicine. 2023. PMID: 37224770 Free PMC article.
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Härkönen J, Pölönen P, Deen AJ, Selvarajan I, Teppo HR, Dimova EY, Kietzmann T, Ahtiainen M, Väyrynen JP, Väyrynen SA, Elomaa H, Tynkkynen N, Eklund T, Kuopio T, Talvitie EM, Taimen P, Kallajoki M, Kaikkonen MU, Heinäniemi M, Levonen AL. Härkönen J, et al. Among authors: selvarajan i. Redox Biol. 2023 May;61:102644. doi: 10.1016/j.redox.2023.102644. Epub 2023 Feb 27. Redox Biol. 2023. PMID: 36867945 Free PMC article.