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SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction.
Deinhardt-Emmer S, Böttcher S, Häring C, Giebeler L, Henke A, Zell R, Jungwirth J, Jordan PM, Werz O, Hornung F, Brandt C, Marquet M, Mosig AS, Pletz MW, Schacke M, Rödel J, Heller R, Nietzsche S, Löffler B, Ehrhardt C. Deinhardt-Emmer S, et al. Among authors: heller r. J Virol. 2021 Apr 26;95(10):e00110-21. doi: 10.1128/JVI.00110-21. Epub 2021 Feb 26. J Virol. 2021. PMID: 33637603 Free PMC article.
Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation.
Ginter T, Bier C, Knauer SK, Sughra K, Hildebrand D, Münz T, Liebe T, Heller R, Henke A, Stauber RH, Reichardt W, Schmid JA, Kubatzky KF, Heinzel T, Krämer OH. Ginter T, et al. Among authors: heller r. Cell Signal. 2012 Jul;24(7):1453-60. doi: 10.1016/j.cellsig.2012.02.018. Epub 2012 Mar 7. Cell Signal. 2012. PMID: 22425562
The anti-obesity drug orlistat reveals anti-viral activity.
Ammer E, Nietzsche S, Rien C, Kühnl A, Mader T, Heller R, Sauerbrei A, Henke A. Ammer E, et al. Among authors: heller r. Med Microbiol Immunol. 2015 Dec;204(6):635-45. doi: 10.1007/s00430-015-0391-4. Epub 2015 Feb 14. Med Microbiol Immunol. 2015. PMID: 25680890
The Peroxisome Proliferator-Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages.
Schubert M, Becher S, Wallert M, Maeß MB, Abhari M, Rennert K, Mosig AS, Große S, Heller R, Grün M, Lorkowski S. Schubert M, et al. Among authors: heller r. Mol Pharmacol. 2020 Mar;97(3):212-225. doi: 10.1124/mol.119.117887. Epub 2019 Dec 23. Mol Pharmacol. 2020. PMID: 31871304
Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model.
Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C, Löffler B, Mosig AS. Deinhardt-Emmer S, et al. Among authors: heller r. Biofabrication. 2020 Feb 19;12(2):025012. doi: 10.1088/1758-5090/ab7073. Biofabrication. 2020. PMID: 31994489
1,424 results