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SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2.
Neuron. 2021.
PMID: 33657413
Free PMC article.
Structural Evolution of TIR-Domain Signalosomes.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot FK, Lim BYJ, McGuinness HY, Zaoti ZF, Li S, Desa S, Manik MK, Nanson JD, Kobe B.
Nimma S, et al. Among authors: mcguinness hy.
Front Immunol. 2021 Nov 17;12:784484. doi: 10.3389/fimmu.2021.784484. eCollection 2021.
Front Immunol. 2021.
PMID: 34868065
Free PMC article.
Review.
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SARM1-Dependent Axon Degeneration: Nucleotide Signaling, Neurodegenerative Disorders, Toxicity, and Therapeutic Opportunities.
McGuinness HY, Gu W, Shi Y, Kobe B, Ve T.
McGuinness HY, et al.
Neuroscientist. 2024 Aug;30(4):473-492. doi: 10.1177/10738584231162508. Epub 2023 Mar 31.
Neuroscientist. 2024.
PMID: 37002660
Free PMC article.
Review.
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TIR domain-associated nucleotides with functions in plant immunity and beyond.
Maruta N, Sorbello M, Lim BYJ, McGuinness HY, Shi Y, Ve T, Kobe B.
Maruta N, et al. Among authors: mcguinness hy.
Curr Opin Plant Biol. 2023 Jun;73:102364. doi: 10.1016/j.pbi.2023.102364. Epub 2023 Apr 20.
Curr Opin Plant Biol. 2023.
PMID: 37086529
Review.
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