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Page 1
Wnt-β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression.
Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Quandt J, et al. Among authors: emmanuel ao. Nat Immunol. 2021 Apr;22(4):471-484. doi: 10.1038/s41590-021-00889-2. Epub 2021 Mar 4. Nat Immunol. 2021. PMID: 33664518 Free PMC article.
β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.
Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. Keerthivasan S, et al. Among authors: emmanuel ao. Sci Transl Med. 2014 Feb 26;6(225):225ra28. doi: 10.1126/scitranslmed.3007607. Sci Transl Med. 2014. PMID: 24574339 Free PMC article.
β-Catenin induces T-cell transformation by promoting genomic instability.
Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. Dose M, et al. Among authors: emmanuel ao. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26. Proc Natl Acad Sci U S A. 2014. PMID: 24371308 Free PMC article.
Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing.
Okoreeh MK, Kennedy DE, Emmanuel AO, Veselits M, Moshin A, Ladd RH, Erickson S, McLean KC, Madrigal B, Nemazee D, Maienschein-Cline M, Mandal M, Clark MR. Okoreeh MK, et al. Among authors: emmanuel ao. Sci Immunol. 2022 Aug 5;7(74):eabm1664. doi: 10.1126/sciimmunol.abm1664. Epub 2022 Aug 5. Sci Immunol. 2022. PMID: 35930652 Free PMC article.
Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.
Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K. Yoshida T, et al. Among authors: emmanuel ao. Genes Dev. 2019 Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23. Genes Dev. 2019. PMID: 31123064 Free PMC article.
Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.
Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Hu Y, et al. Among authors: emmanuel ao. Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116. Genes Dev. 2016. PMID: 27664237 Free PMC article.