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Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells.
Wanjalla CN, McDonnell WJ, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Guo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR. Wanjalla CN, et al. Among authors: simmons jd. Cell Rep Med. 2021 Feb 16;2(2):100205. doi: 10.1016/j.xcrm.2021.100205. eCollection 2021 Feb 16. Cell Rep Med. 2021. PMID: 33665640 Free PMC article.
Adipose Tissue in Persons With HIV Is Enriched for CD4+ T Effector Memory and T Effector Memory RA+ Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance.
Wanjalla CN, McDonnell WJ, Barnett L, Simmons JD, Furch BD, Lima MC, Woodward BO, Fan R, Fei Y, Baker PG, Ram R, Pilkinton MA, Mashayekhi M, Brown NJ, Mallal SA, Kalams SA, Koethe JR. Wanjalla CN, et al. Among authors: simmons jd. Front Immunol. 2019 Mar 19;10:408. doi: 10.3389/fimmu.2019.00408. eCollection 2019. Front Immunol. 2019. PMID: 30941121 Free PMC article.
Humoral and cellular immune responses to the SARS-CoV-2 BNT162b2 vaccine among a cohort of solid organ transplant recipients and healthy controls.
Yanis A, Haddadin Z, Spieker AJ, Waqfi D, Rankin DA, Talj R, Thomas L, Birdwell KA, Ezzell L, Blair M, Eason J, Varjabedian R, Warren CM, Nochowicz CH, Olson EC, Simmons JD, Yoder S, Guy M, Thomsen I, Chappell JD, Kalams SA, Halasa NB. Yanis A, et al. Among authors: simmons jd. Transpl Infect Dis. 2022 Feb;24(1):e13772. doi: 10.1111/tid.13772. Epub 2021 Dec 21. Transpl Infect Dis. 2022. PMID: 34905653 Free PMC article.
The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells.
Mashayekhi M, Wanjalla CN, Warren CM, Simmons JD, Ghoshal K, Pilkinton M, Bailin SS, Gabriel CL, Pozzi A, Koethe JR, Brown NJ, Kalams SA, Luther JM. Mashayekhi M, et al. Among authors: simmons jd. Prostaglandins Other Lipid Mediat. 2022 Feb;158:106604. doi: 10.1016/j.prostaglandins.2021.106604. Epub 2021 Dec 15. Prostaglandins Other Lipid Mediat. 2022. PMID: 34922004 Free PMC article.
Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response.
Currenti J, Simmons J, Oakes J, Gaudieri S, Warren CM, Gangula R, Alves E, Ram R, Leary S, Armitage JD, Smith RM, Chopra A, Halasa NB, Pilkinton MA, Kalams SA. Currenti J, et al. Among authors: simmons j. Front Immunol. 2023 Mar 29;14:1133781. doi: 10.3389/fimmu.2023.1133781. eCollection 2023. Front Immunol. 2023. PMID: 37063867 Free PMC article.
CD3+ T-cell: CD14+monocyte complexes are dynamic and increased with HIV and glucose intolerance.
Obare LM, Simmons J, Oakes J, Zhang X, Nochowicz C, Priest S, Bailin SS, Warren CM, Mashayekhi M, Beasley HK, Shao J, Meenderink LM, Sheng Q, Stolze J, Gangula R, Absi T, Su YR, Neikirk K, Chopra A, Gabriel CL, Temu T, Pakala S, Wilfong EM, Gianella S, Phillips EJ, Harrison DG, Hinton A, Kalams SA, Kirabo A, Mallal SA, Koethe JR, Wanjalla CN. Obare LM, et al. bioRxiv [Preprint]. 2024 Jun 20:2023.04.24.538020. doi: 10.1101/2023.04.24.538020. bioRxiv. 2024. PMID: 37162990 Free PMC article. Preprint.
Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV.
Bailin SS, Kropski JA, Gangula RD, Hannah L, Simmons JD, Mashayekhi M, Ye F, Fan R, Mallal S, Warren CM, Kalams SA, Gabriel CL, Wanjalla CN, Koethe JR. Bailin SS, et al. Among authors: simmons jd. Front Immunol. 2023 Aug 30;14:1152003. doi: 10.3389/fimmu.2023.1152003. eCollection 2023. Front Immunol. 2023. PMID: 37711619 Free PMC article.
Single-cell Analysis of Subcutaneous Fat Reveals Pro-fibrotic Cells that Correlate with Visceral Adiposity in HIV.
Bailin SS, Gabriel CL, Gangula RD, Hannah L, Nair S, Carr JJ, Terry JG, Silver HJ, Simmons JD, Mashayekhi M, Kalams SA, Mallal S, Kropski JA, Wanjalla CN, Koethe JR. Bailin SS, et al. Among authors: simmons jd. J Clin Endocrinol Metab. 2024 May 31:dgae369. doi: 10.1210/clinem/dgae369. Online ahead of print. J Clin Endocrinol Metab. 2024. PMID: 38820087
181 results