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Clarifying the translational potential of B-I09.
Del Valle JR, Betts BC, Yu XZ, Janssens S, Lambrecht BN, Simon MC, Hu CA. Del Valle JR, et al. Among authors: hu ca. Nat Chem Biol. 2020 Nov;16(11):1152. doi: 10.1038/s41589-020-00654-w. Nat Chem Biol. 2020. PMID: 33067597 Free PMC article. No abstract available.
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L. Ji Y, et al. Among authors: hu ca. Nat Cell Biol. 2023 May;25(5):726-739. doi: 10.1038/s41556-023-01138-4. Epub 2023 May 4. Nat Cell Biol. 2023. PMID: 37142791 Free PMC article.
Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Yoshida S, Wei X, Zhang G, O'Connor CL, Torres M, Zhou Z, Lin L, Menon R, Xu X, Zheng W, Xiong Y, Otto E, Tang CA, Hua R, Verma R, Mori H, Zhang Y, Hu CA, Liu M, Garg P, Hodgin JB, Sun S, Bitzer M, Qi L. Yoshida S, et al. Among authors: hu ca. J Clin Invest. 2021 Apr 1;131(7):e143988. doi: 10.1172/JCI143988. J Clin Invest. 2021. PMID: 33591954 Free PMC article.
An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.
Ricci D, Tutton S, Marrocco I, Ying M, Blumenthal D, Eletto D, Vargas J, Boyle S, Fazelinia H, Qian L, Suresh K, Taylor D, Paton JC, Paton AW, Tang CA, Hu CA, Radhakrishnan R, Gidalevitz T, Argon Y. Ricci D, et al. Among authors: hu ca. J Biol Chem. 2021 Jan-Jun;296:100781. doi: 10.1016/j.jbc.2021.100781. Epub 2021 May 14. J Biol Chem. 2021. PMID: 34000298 Free PMC article.
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer.
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang CA, Wu S, Zhou W, Guo D, Karakashev S, Hu CA, Sarma K, Kossenkov AV, Zhang R. Lin J, et al. Among authors: hu ca. Nat Commun. 2021 Sep 7;12(1):5321. doi: 10.1038/s41467-021-25684-3. Nat Commun. 2021. PMID: 34493732 Free PMC article.
Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer.
Tcyganov EN, Hanabuchi S, Hashimoto A, Campbell D, Kar G, Slidel TW, Cayatte C, Landry A, Pilataxi F, Hayes S, Dougherty B, Hicks KC, Mulgrew K, Tang CA, Hu CA, Guo W, Grivennikov S, Ali MA, Beltra JC, Wherry EJ, Nefedova Y, Gabrilovich DI. Tcyganov EN, et al. Among authors: hu ca. J Clin Invest. 2021 Aug 16;131(16):e145971. doi: 10.1172/JCI145971. J Clin Invest. 2021. PMID: 34228641 Free PMC article.
126 results