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The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.
Mateos-Gomez PA, Kent T, Deng SK, McDevitt S, Kashkina E, Hoang TM, Pomerantz RT, Sfeir A. Mateos-Gomez PA, et al. Among authors: kent t. Nat Struct Mol Biol. 2017 Dec;24(12):1116-1123. doi: 10.1038/nsmb.3494. Epub 2017 Oct 23. Nat Struct Mol Biol. 2017. PMID: 29058711 Free PMC article.
Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids.
Ozdemir AY, Rusanov T, Kent T, Siddique LA, Pomerantz RT. Ozdemir AY, et al. Among authors: kent t. J Biol Chem. 2018 Apr 6;293(14):5259-5269. doi: 10.1074/jbc.RA117.000565. Epub 2018 Feb 14. J Biol Chem. 2018. PMID: 29444826 Free PMC article.
How RNA transcripts coordinate DNA recombination and repair.
McDevitt S, Rusanov T, Kent T, Chandramouly G, Pomerantz RT. McDevitt S, et al. Among authors: kent t. Nat Commun. 2018 Mar 15;9(1):1091. doi: 10.1038/s41467-018-03483-7. Nat Commun. 2018. PMID: 29545568 Free PMC article.
519 results