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HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie C, Van Den Bosch L, Van Damme P. Fazal R, et al. Among authors: pakravan d. EMBO J. 2021 Apr 1;40(7):e106177. doi: 10.15252/embj.2020106177. Epub 2021 Mar 10. EMBO J. 2021. PMID: 33694180 Free PMC article.
F/YGG-motif is an intrinsically disordered nucleic-acid binding motif.
Van Lindt J, Lazar T, Pakravan D, Demulder M, Meszaros A, Van Den Bosch L, Maes D, Tompa P. Van Lindt J, et al. Among authors: pakravan d. RNA Biol. 2022;19(1):622-635. doi: 10.1080/15476286.2022.2066336. Epub 2021 Dec 31. RNA Biol. 2022. PMID: 35491929 Free PMC article.
Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS.
Tejido C, Pakravan D, Bosch LVD. Tejido C, et al. Among authors: pakravan d. Front Mol Neurosci. 2021 Aug 9;14:686995. doi: 10.3389/fnmol.2021.686995. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34434087 Free PMC article. Review.
14 results