Dai N - Search Results

1

RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression.

Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N. Regué L, et al. Among authors: dai n. Mol Metab. 2021 Jun;48:101209. doi: 10.1016/j.molmet.2021.101209. Epub 2021 Mar 9. Mol Metab. 2021. PMID: 33705986 Free PMC article.

2

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.

Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. Dai N, et al. Cell Metab. 2015 Apr 7;21(4):609-21. doi: 10.1016/j.cmet.2015.03.006. Cell Metab. 2015. PMID: 25863250 Free PMC article.

3

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.

Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J. Regué L, et al. Among authors: dai n. Mol Cell Biol. 2019 Mar 19;39(7):e00528-18. doi: 10.1128/MCB.00528-18. Print 2019 Apr 1. Mol Cell Biol. 2019. PMID: 30692269 Free PMC article.

4

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.

Regué L, Minichiello L, Avruch J, Dai N. Regué L, et al. Among authors: dai n. J Biol Chem. 2019 Aug 2;294(31):11944-11951. doi: 10.1074/jbc.RA119.008778. Epub 2019 Jun 17. J Biol Chem. 2019. PMID: 31209109 Free PMC article.

5

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.

Regué L, Wang W, Ji F, Avruch J, Wang H, Dai N. Regué L, et al. Among authors: dai n. Diabetes. 2023 Jan 1;72(1):33-44. doi: 10.2337/db21-1087. Diabetes. 2023. PMID: 36219823 Free PMC article.

6

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J. Dai N, et al. Genes Dev. 2011 Jun 1;25(11):1159-72. doi: 10.1101/gad.2042311. Epub 2011 May 16. Genes Dev. 2011. PMID: 21576258 Free PMC article.

7

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.

Dai N, Christiansen J, Nielsen FC, Avruch J. Dai N, et al. Genes Dev. 2013 Feb 1;27(3):301-12. doi: 10.1101/gad.209130.112. Genes Dev. 2013. PMID: 23388827 Free PMC article.

8

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.

Dai N, Ji F, Wright J, Minichiello L, Sadreyev R, Avruch J. Dai N, et al. Elife. 2017 Jul 28;6:e27155. doi: 10.7554/eLife.27155. Elife. 2017. PMID: 28753127 Free PMC article.

9

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ. Greenwald WW, et al. Among authors: dai n. Nat Commun. 2019 May 7;10(1):2078. doi: 10.1038/s41467-019-09975-4. Nat Commun. 2019. PMID: 31064983 Free PMC article.

10

Amino acid regulation of TOR complex 1.

Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N. Avruch J, et al. Among authors: dai n. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E592-602. doi: 10.1152/ajpendo.90645.2008. Epub 2008 Sep 2. Am J Physiol Endocrinol Metab. 2009. PMID: 18765678 Free PMC article. Review.

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