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Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.
Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME. Pei F, et al. Among authors: henderson mj. Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y. Sci Rep. 2017. PMID: 29259176 Free PMC article.
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Henderson MJ, Trychta KA, Yang SM, Bäck S, Yasgar A, Wires ES, Danchik C, Yan X, Yano H, Shi L, Wu KJ, Wang AQ, Tao D, Zahoránszky-Kőhalmi G, Hu X, Xu X, Maloney D, Zakharov AV, Rai G, Urano F, Airavaara M, Gavrilova O, Jadhav A, Wang Y, Simeonov A, Harvey BK. Henderson MJ, et al. Cell Rep. 2021 Apr 27;35(4):109040. doi: 10.1016/j.celrep.2021.109040. Cell Rep. 2021. PMID: 33910017 Free PMC article.
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
Frankowski KJ, Patnaik S, Wang C, Southall N, Dutta D, De S, Li D, Dextras C, Lin YH, Bryant-Connah M, Davis D, Wang F, Wachsmuth LM, Shah P, Williams J, Kabir M, Zhu E, Baljinnyam B, Wang A, Xu X, Norton J, Ferrer M, Titus S, Simeonov A, Zheng W, Mathews Griner LA, Jadhav A, Aubé J, Henderson MJ, Rudloff U, Schoenen FJ, Huang S, Marugan JJ. Frankowski KJ, et al. Among authors: henderson mj. J Med Chem. 2022 Jun 23;65(12):8303-8331. doi: 10.1021/acs.jmedchem.2c00204. Epub 2022 Jun 13. J Med Chem. 2022. PMID: 35696646 Free PMC article.
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement.
Sanchez TW, Ronzetti MH, Owens AE, Antony M, Voss T, Wallgren E, Talley D, Balakrishnan K, Leyes Porello SE, Rai G, Marugan JJ, Michael SG, Baljinnyam B, Southall N, Simeonov A, Henderson MJ. Sanchez TW, et al. Among authors: henderson mj. ACS Chem Biol. 2022 Sep 16;17(9):2471-2482. doi: 10.1021/acschembio.2c00334. Epub 2022 Sep 1. ACS Chem Biol. 2022. PMID: 36049119 Free PMC article.
Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2.
Esteban-Lopez M, Wilson KJ, Myhr C, Kaftanovskaya EM, Henderson MJ, Southall NT, Xu X, Wang A, Hu X, Barnaeva E, Ye W, George ER, Sherrill JT, Ferrer M, Morello R, Agoulnik IU, Marugan JJ, Agoulnik AI. Esteban-Lopez M, et al. Among authors: henderson mj. Commun Biol. 2022 Nov 4;5(1):1183. doi: 10.1038/s42003-022-04143-9. Commun Biol. 2022. PMID: 36333465 Free PMC article.
248 results