IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.
Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE.
Ashpole NM, et al.
Geroscience. 2017 Apr;39(2):129-145. doi: 10.1007/s11357-017-9971-0. Epub 2017 Apr 13.
Geroscience. 2017.
PMID: 28409331
Free PMC article.