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A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids.
Clarke JD, Duyvesteyn HME, Perez-Martin E, Latišenko U, Porta C, Humphreys KV, Hay AL, Ren J, Fry EE, van den Born E, Charleston B, Bonnet-Di Placido M, Owens RJ, Stuart DI, Hammond JA. Clarke JD, et al. Among authors: duyvesteyn hme. J Gen Virol. 2024 Oct;105(10):002032. doi: 10.1099/jgv.0.002032. J Gen Virol. 2024. PMID: 39422666 Free PMC article.
Structural insights into Frizzled3 through nanobody modulators.
Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza RR, Chang TH, Yi G, Duyvesteyn HME, Yu J, Lu W, Pardon E, Steyaert J, Zhu Y, Ni T, Jones EY. Hillier J, et al. Among authors: duyvesteyn hme. Nat Commun. 2024 Aug 22;15(1):7228. doi: 10.1038/s41467-024-51451-1. Nat Commun. 2024. PMID: 39174501 Free PMC article.
Concerted deletions eliminate a neutralizing supersite in SARS-CoV-2 BA.2.87.1 spike.
Duyvesteyn HME, Dijokaite-Guraliuc A, Liu C, Supasa P, Kronsteiner B, Jeffery K, Stafford L, Klenerman P, Dunachie SJ; PITCH Consortium; Mongkolsapaya J, Fry EE, Ren J, Stuart DI, Screaton GR. Duyvesteyn HME, et al. Structure. 2024 Oct 3;32(10):1594-1602.e6. doi: 10.1016/j.str.2024.07.020. Epub 2024 Aug 21. Structure. 2024. PMID: 39173622 Free article.
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI, Ritter TG, Plowright M, Newman TAH, Stafford L, Kronsteiner B, Temperton N, Lui Y, Fellermeyer M, Goulder P, Klenerman P, Dunachie SJ, Barton MI, Kutuzov MA, Dushek O; OPTIC Consortium; Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Liu C, et al. Among authors: duyvesteyn hme. Cell Rep Med. 2024 May 21;5(5):101553. doi: 10.1016/j.xcrm.2024.101553. Epub 2024 May 8. Cell Rep Med. 2024. PMID: 38723626 Free PMC article.
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Liu C, Das R, Dijokaite-Guraliuc A, Zhou D, Mentzer AJ, Supasa P, Selvaraj M, Duyvesteyn HME, Ritter TG, Temperton N, Klenerman P, Dunachie SJ, Paterson NG, Williams MA, Hall DR, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Liu C, et al. Among authors: duyvesteyn hme. Nat Commun. 2024 Apr 16;15(1):3284. doi: 10.1038/s41467-024-47393-3. Nat Commun. 2024. PMID: 38627386 Free PMC article.
The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86.
Zhou D, Supasa P, Liu C, Dijokaite-Guraliuc A, Duyvesteyn HME, Selvaraj M, Mentzer AJ, Das R, Dejnirattisai W, Temperton N, Klenerman P, Dunachie SJ, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR. Zhou D, et al. Among authors: duyvesteyn hme. Nat Commun. 2024 Mar 28;15(1):2734. doi: 10.1038/s41467-024-46982-6. Nat Commun. 2024. PMID: 38548763 Free PMC article.
ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface.
Ni T, Mendonça L, Zhu Y, Howe A, Radecke J, Shah PM, Sheng Y, Krebs AS, Duyvesteyn HME, Allen E, Lambe T, Bisset C, Spencer A, Morris S, Stuart DI, Gilbert S, Zhang P. Ni T, et al. Among authors: duyvesteyn hme. iScience. 2023 Sep 12;26(10):107882. doi: 10.1016/j.isci.2023.107882. eCollection 2023 Oct 20. iScience. 2023. PMID: 37766989 Free PMC article.
Accelerating drug target inhibitor discovery with a deep generative foundation model.
Chenthamarakshan V, Hoffman SC, Owen CD, Lukacik P, Strain-Damerell C, Fearon D, Malla TR, Tumber A, Schofield CJ, Duyvesteyn HME, Dejnirattisai W, Carrique L, Walter TS, Screaton GR, Matviiuk T, Mojsilovic A, Crain J, Walsh MA, Stuart DI, Das P. Chenthamarakshan V, et al. Among authors: duyvesteyn hme. Sci Adv. 2023 Jun 23;9(25):eadg7865. doi: 10.1126/sciadv.adg7865. Epub 2023 Jun 21. Sci Adv. 2023. PMID: 37343087 Free PMC article.
44 results