Rock JM - Search Results

1

CRISPY-BRED and CRISPY-BRIP: efficient bacteriophage engineering.

Wetzel KS, Guerrero-Bustamante CA, Dedrick RM, Ko CC, Freeman KG, Aull HG, Divens AM, Rock JM, Zack KM, Hatfull GF. Wetzel KS, et al. Among authors: rock jm. Sci Rep. 2021 Mar 24;11(1):6796. doi: 10.1038/s41598-021-86112-6. Sci Rep. 2021. PMID: 33762639 Free PMC article.

2

Tuberculosis drug discovery in the CRISPR era.

Rock J. Rock J. PLoS Pathog. 2019 Sep 19;15(9):e1007975. doi: 10.1371/journal.ppat.1007975. eCollection 2019 Sep. PLoS Pathog. 2019. PMID: 31536613 Free PMC article.

3

CRISPR Interference (CRISPRi) for Targeted Gene Silencing in Mycobacteria.

Wong AI, Rock JM. Wong AI, et al. Among authors: rock jm. Methods Mol Biol. 2021;2314:343-364. doi: 10.1007/978-1-0716-1460-0_16. Methods Mol Biol. 2021. PMID: 34235662

4

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens.

Choudhery S, DeJesus MA, Srinivasan A, Rock J, Schnappinger D, Ioerger TR. Choudhery S, et al. PLoS Comput Biol. 2024 May 20;20(5):e1011408. doi: 10.1371/journal.pcbi.1011408. eCollection 2024 May. PLoS Comput Biol. 2024. PMID: 38768228 Free PMC article.

5

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

Bosch B, DeJesus MA, Poulton NC, Zhang W, Engelhart CA, Zaveri A, Lavalette S, Ruecker N, Trujillo C, Wallach JB, Li S, Ehrt S, Chait BT, Schnappinger D, Rock JM. Bosch B, et al. Among authors: rock jm. Cell. 2021 Aug 19;184(17):4579-4592.e24. doi: 10.1016/j.cell.2021.06.033. Epub 2021 Jul 22. Cell. 2021. PMID: 34297925 Free PMC article.

6

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis.

Li S, Poulton NC, Chang JS, Azadian ZA, DeJesus MA, Ruecker N, Zimmerman MD, Eckartt KA, Bosch B, Engelhart CA, Sullivan DF, Gengenbacher M, Dartois VA, Schnappinger D, Rock JM. Li S, et al. Among authors: rock jm. Nat Microbiol. 2022 Jun;7(6):766-779. doi: 10.1038/s41564-022-01130-y. Epub 2022 May 30. Nat Microbiol. 2022. PMID: 35637331 Free PMC article.

7

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM. Carey AF, et al. Among authors: rock jm. PLoS Pathog. 2018 Mar 5;14(3):e1006939. doi: 10.1371/journal.ppat.1006939. eCollection 2018 Mar. PLoS Pathog. 2018. PMID: 29505613 Free PMC article.

8

The essential M. tuberculosis Clp protease is functionally asymmetric in vivo.

d'Andrea FB, Poulton NC, Froom R, Tam K, Campbell EA, Rock JM. d'Andrea FB, et al. Among authors: rock jm. Sci Adv. 2022 May 6;8(18):eabn7943. doi: 10.1126/sciadv.abn7943. Epub 2022 May 4. Sci Adv. 2022. PMID: 35507665 Free PMC article.

9

Iron limitation in M. tuberculosis has broad impact on central carbon metabolism.

Theriault ME, Pisu D, Wilburn KM, Lê-Bury G, MacNamara CW, Michael Petrassi H, Love M, Rock JM, VanderVen BC, Russell DG. Theriault ME, et al. Among authors: rock jm. Commun Biol. 2022 Jul 9;5(1):685. doi: 10.1038/s42003-022-03650-z. Commun Biol. 2022. PMID: 35810253 Free PMC article.

10

Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis.

Poulton NC, Azadian ZA, DeJesus MA, Rock JM. Poulton NC, et al. Among authors: rock jm. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0090422. doi: 10.1128/aac.00904-22. Epub 2022 Aug 3. Antimicrob Agents Chemother. 2022. PMID: 35920665 Free PMC article.

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