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CD8+ T cells inhibit metastasis and CXCL4 regulates its function.
Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. Joseph R, et al. Among authors: varadarajan n. Br J Cancer. 2021 Jul;125(2):176-189. doi: 10.1038/s41416-021-01338-5. Epub 2021 Apr 1. Br J Cancer. 2021. PMID: 33795809 Free PMC article.
Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.
Ritthipichai K, Haymaker CL, Martinez M, Aschenbrenner A, Yi X, Zhang M, Kale C, Vence LM, Roszik J, Hailemichael Y, Overwijk WW, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, Bernatchez C. Ritthipichai K, et al. Among authors: varadarajan n. Clin Cancer Res. 2017 Oct 15;23(20):6151-6164. doi: 10.1158/1078-0432.CCR-16-1217. Epub 2017 Jul 28. Clin Cancer Res. 2017. PMID: 28754817 Free PMC article.
Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.
Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Soundararajan R, et al. Among authors: varadarajan n. Cancers (Basel). 2019 May 24;11(5):714. doi: 10.3390/cancers11050714. Cancers (Basel). 2019. PMID: 31137625 Free PMC article. Review.
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N. Fousek K, et al. Among authors: varadarajan n. Leukemia. 2021 Jan;35(1):75-89. doi: 10.1038/s41375-020-0792-2. Epub 2020 Mar 24. Leukemia. 2021. PMID: 32205861 Free PMC article.
Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells.
Rath JA, Bajwa G, Carreres B, Hoyer E, Gruber I, Martínez-Paniagua MA, Yu YR, Nouraee N, Sadeghi F, Wu M, Wang T, Hebeisen M, Rufer N, Varadarajan N, Ho PC, Brenner MK, Gfeller D, Arber C. Rath JA, et al. Among authors: varadarajan n. Sci Adv. 2020 Jul 3;6(27):eaaz7809. doi: 10.1126/sciadv.aaz7809. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32923584 Free PMC article.
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils.
Yang DS, Saeedi A, Davtyan A, Fathi M, Sherman MB, Safari MS, Klindziuk A, Barton MC, Varadarajan N, Kolomeisky AB, Vekilov PG. Yang DS, et al. Among authors: varadarajan n. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2015618118. doi: 10.1073/pnas.2015618118. Proc Natl Acad Sci U S A. 2021. PMID: 33653952 Free PMC article.
Designed improvement to T-cell immunotherapy by multidimensional single cell profiling.
Bandey IN, Adolacion JRT, Romain G, Paniagua MM, An X, Saeedi A, Liadi I, You Z, Rajanayake RB, Hwu P, Singh H, Cooper LJ, Varadarajan N. Bandey IN, et al. Among authors: varadarajan n. J Immunother Cancer. 2021 Mar;9(3):e001877. doi: 10.1136/jitc-2020-001877. J Immunother Cancer. 2021. PMID: 33722906 Free PMC article.
82 results