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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Vandyck K, Abdelnabi R, Gupta K, Jochmans D, Jekle A, Deval J, Misner D, Bardiot D, Foo CS, Liu C, Ren S, Beigelman L, Blatt LM, Boland S, Vangeel L, Dejonghe S, Chaltin P, Marchand A, Serebryany V, Stoycheva A, Chanda S, Symons JA, Raboisson P, Neyts J. Vandyck K, et al. Among authors: marchand a. Biochem Biophys Res Commun. 2021 May 28;555:134-139. doi: 10.1016/j.bbrc.2021.03.096. Epub 2021 Mar 26. Biochem Biophys Res Commun. 2021. PMID: 33813272 Free PMC article.
Antifungal carbazoles.
Thevissen K, Marchand A, Chaltin P, Meert EM, Cammue BP. Thevissen K, et al. Among authors: marchand a. Curr Med Chem. 2009;16(17):2205-11. doi: 10.2174/092986709788612701. Curr Med Chem. 2009. PMID: 19519387 Review.
Identification and characterization of 4-[4-(3-phenyl-2-propen-1-yl)-1-piperazinyl]-5H-pyrimido[5,4-b]indole derivatives as Salmonella biofilm inhibitors.
Robijns SC, De Pauw B, Loosen B, Marchand A, Chaltin P, De Keersmaecker SC, Vanderleyden J, Steenackers HP. Robijns SC, et al. Among authors: marchand a. FEMS Immunol Med Microbiol. 2012 Jul;65(2):390-4. doi: 10.1111/j.1574-695X.2012.00973.x. Epub 2012 May 8. FEMS Immunol Med Microbiol. 2012. PMID: 22487085 Free article.
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.
Christ F, Shaw S, Demeulemeester J, Desimmie BA, Marchand A, Butler S, Smets W, Chaltin P, Westby M, Debyser Z, Pickford C. Christ F, et al. Among authors: marchand a. Antimicrob Agents Chemother. 2012 Aug;56(8):4365-74. doi: 10.1128/AAC.00717-12. Epub 2012 Jun 4. Antimicrob Agents Chemother. 2012. PMID: 22664975 Free PMC article.
Identification of novel FLT3 kinase inhibitors.
Pauwels D, Klaassen H, Lahortiga I, Kilonda A, Jacobs K, Sweron B, Corbau R, Chaltin P, Marchand A, Cools J. Pauwels D, et al. Among authors: marchand a. Eur J Med Chem. 2013 May;63:713-21. doi: 10.1016/j.ejmech.2013.03.024. Epub 2013 Mar 21. Eur J Med Chem. 2013. PMID: 23567961
597 results