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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.
Edwards CT, Karunakaran KA, Garcia E, Beutler N, Gagne M, Golden N, Aoued H, Pellegrini KL, Burnett MR, Honeycutt CC, Lapp SA, Ton T, Lin MC, Metz A, Bombin A, Goff K, Scheuermann SE, Wilkes A, Wood JS, Ehnert S, Weissman S, Curran EH, Roy M, Dessasau E, Paiardini M, Upadhyay AA, Moore I, Maness NJ, Douek DC, Piantadosi A, Andrabi R, Rogers TR, Burton DR, Bosinger SE. Edwards CT, et al. Among authors: beutler n. bioRxiv [Preprint]. 2024 Jul 30:2024.07.30.605768. doi: 10.1101/2024.07.30.605768. bioRxiv. 2024. PMID: 39109178 Free PMC article. Preprint.
Correction to "Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead".
Elshan NGRD, Wolff KC, Riva L, Woods AK, Grabovyi G, Wilson K, Pedroarena J, Ghorai S, Nazarian A, Weiss F, Liu Y, Mazumdar W, Song L, Okwor N, Malvin J, Liu D, Bakowski MA, Beutler N, Kirkpatrick MG, Gebara-Lamb A, Huang E, Nguyen-Tran VTB, Chi V, Li S, Rogers TF, McNamara CW, Gupta AK, Rahimi A, Chen JJ, Joseph SB, Schultz PG, Chatterjee AK. Elshan NGRD, et al. Among authors: beutler n. J Med Chem. 2024 Jun 27;67(12):10508-10509. doi: 10.1021/acs.jmedchem.4c01269. Epub 2024 Jun 14. J Med Chem. 2024. PMID: 38875353 Free PMC article. No abstract available.
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes.
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Burbach S, Truong A, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B. Hurtado J, et al. Among authors: beutler n. Cell Rep. 2024 Jun 25;43(6):114307. doi: 10.1016/j.celrep.2024.114307. Epub 2024 Jun 5. Cell Rep. 2024. PMID: 38848216 Free article.
Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Warhead.
Dayan Elshan NGR, Wolff KC, Riva L, Woods AK, Grabovyi G, Wilson K, Pedroarena J, Ghorai S, Nazarian A, Weiss F, Liu Y, Mazumdar W, Song L, Okwor N, Malvin J, Bakowski MA, Beutler N, Kirkpatrick MG, Gebara-Lamb A, Huang E, Nguyen-Tran VTB, Chi V, Li S, Rogers TF, McNamara CW, Gupta AK, Rahimi A, Chen JJ, Joseph SB, Schultz PG, Chatterjee AK. Dayan Elshan NGR, et al. Among authors: beutler n. J Med Chem. 2024 Feb 22;67(4):2369-2378. doi: 10.1021/acs.jmedchem.3c01938. Epub 2024 Feb 9. J Med Chem. 2024. PMID: 38335279 Free PMC article.
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection.
Martin GM, Torres JL, Pholcharee T, Oyen D, Flores-Garcia Y, Gibson G, Moskovitz R, Beutler N, Jung DD, Copps J, Lee WH, Gonzalez-Paez G, Emerling D, MacGill RS, Locke E, King CR, Zavala F, Wilson IA, Ward AB. Martin GM, et al. Among authors: beutler n. Nat Commun. 2023 Jul 28;14(1):4546. doi: 10.1038/s41467-023-40151-x. Nat Commun. 2023. PMID: 37507365 Free PMC article.
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes.
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B. Hurtado J, et al. Among authors: beutler n. bioRxiv [Preprint]. 2023 Mar 31:2023.03.28.534602. doi: 10.1101/2023.03.28.534602. bioRxiv. 2023. Update in: Cell Rep. 2024 Jun 25;43(6):114307. doi: 10.1016/j.celrep.2024.114307 PMID: 37034676 Free PMC article. Updated. Preprint.
Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease.
Zhou P, Song G, Liu H, Yuan M, He WT, Beutler N, Zhu X, Tse LV, Martinez DR, Schäfer A, Anzanello F, Yong P, Peng L, Dueker K, Musharrafieh R, Callaghan S, Capozzola T, Limbo O, Parren M, Garcia E, Rawlings SA, Smith DM, Nemazee D, Jardine JG, Safonova Y, Briney B, Rogers TF, Wilson IA, Baric RS, Gralinski LE, Burton DR, Andrabi R. Zhou P, et al. Among authors: beutler n. Immunity. 2023 Mar 14;56(3):669-686.e7. doi: 10.1016/j.immuni.2023.02.005. Epub 2023 Feb 16. Immunity. 2023. PMID: 36889306 Free PMC article.
Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection.
Oh CK, Nakamura T, Beutler N, Zhang X, Piña-Crespo J, Talantova M, Ghatak S, Trudler D, Carnevale LN, McKercher SR, Bakowski MA, Diedrich JK, Roberts AJ, Woods AK, Chi V, Gupta AK, Rosenfeld MA, Kearns FL, Casalino L, Shaabani N, Liu H, Wilson IA, Amaro RE, Burton DR, Yates JR 3rd, Becker C, Rogers TF, Chatterjee AK, Lipton SA. Oh CK, et al. Among authors: beutler n. Nat Chem Biol. 2023 Mar;19(3):275-283. doi: 10.1038/s41589-022-01149-6. Epub 2022 Sep 29. Nat Chem Biol. 2023. PMID: 36175661 Free PMC article.
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters.
Chaturvedi S, Beutler N, Pablo M, Vasen G, Chen X, Calia G, Buie L, Rodick R, Smith D, Rogers T, Weinberger LS. Chaturvedi S, et al. Among authors: beutler n. bioRxiv [Preprint]. 2022 Aug 11:2022.08.10.503534. doi: 10.1101/2022.08.10.503534. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2204624119. doi: 10.1073/pnas.2204624119 PMID: 35982679 Free PMC article. Updated. Preprint.
40 results