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Targeting mutant KRAS.
Erlanson DA, Webster KR. Erlanson DA, et al. Curr Opin Chem Biol. 2021 Jun;62:101-108. doi: 10.1016/j.cbpa.2021.02.010. Epub 2021 Apr 7. Curr Opin Chem Biol. 2021. PMID: 33838397 Review.
Fragment-based lead discovery: a chemical update.
Erlanson DA. Erlanson DA. Curr Opin Biotechnol. 2006 Dec;17(6):643-52. doi: 10.1016/j.copbio.2006.10.007. Epub 2006 Nov 3. Curr Opin Biotechnol. 2006. PMID: 17084612 Review.
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Gua C, Liu Y, Liu Y, Lulla M, Marcotte D, Marx I, McDowell B, Mertsching E, Negrou E, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M. Hopkins BT, et al. Among authors: erlanson da. Bioorg Med Chem. 2021 Aug 15;44:116275. doi: 10.1016/j.bmc.2021.116275. Epub 2021 Jun 15. Bioorg Med Chem. 2021. PMID: 34314938
Tethering: fragment-based drug discovery.
Erlanson DA, Wells JA, Braisted AC. Erlanson DA, et al. Annu Rev Biophys Biomol Struct. 2004;33:199-223. doi: 10.1146/annurev.biophys.33.110502.140409. Annu Rev Biophys Biomol Struct. 2004. PMID: 15139811 Review.
Fragment-based drug discovery.
Erlanson DA, McDowell RS, O'Brien T. Erlanson DA, et al. J Med Chem. 2004 Jul 1;47(14):3463-82. doi: 10.1021/jm040031v. J Med Chem. 2004. PMID: 15214773 Review. No abstract available.
Fragment-to-Lead Medicinal Chemistry Publications in 2020.
de Esch IJP, Erlanson DA, Jahnke W, Johnson CN, Walsh L. de Esch IJP, et al. Among authors: erlanson da. J Med Chem. 2022 Jan 13;65(1):84-99. doi: 10.1021/acs.jmedchem.1c01803. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928151 Free PMC article. Review.
46 results