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Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2.
Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. Deepak P, et al. Among authors: thapa m. medRxiv [Preprint]. 2021 Apr 9:2021.04.05.21254656. doi: 10.1101/2021.04.05.21254656. medRxiv. 2021. Update in: Ann Intern Med. 2021 Nov;174(11):1572-1585. doi: 10.7326/M21-1757 PMID: 33851176 Free PMC article. Updated. Preprint.
SARS-CoV-2 variants show resistance to neutralization by many monoclonal and serum-derived polyclonal antibodies.
Diamond M, Chen R, Xie X, Case J, Zhang X, VanBlargan L, Liu Y, Liu J, Errico J, Winkler E, Suryadevara N, Tahan S, Turner J, Kim W, Schmitz A, Thapa M, Wang D, Boon A, Pinto D, Presti R, O'Halloran J, Kim A, Deepak P, Fremont D, Corti D, Virgin H, Crowe J, Droit L, Ellebedy A, Shi PY, Gilchuk P. Diamond M, et al. Among authors: thapa m. Res Sq [Preprint]. 2021 Feb 10:rs.3.rs-228079. doi: 10.21203/rs.3.rs-228079/v1. Res Sq. 2021. Update in: Nat Med. 2021 Apr;27(4):717-726. doi: 10.1038/s41591-021-01294-w PMID: 33594356 Free PMC article. Updated. Preprint.
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O'Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS. Chen RE, et al. Among authors: thapa m. Nat Med. 2021 Apr;27(4):717-726. doi: 10.1038/s41591-021-01294-w. Epub 2021 Mar 4. Nat Med. 2021. PMID: 33664494 Free PMC article.
The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD.
Amanat F, Thapa M, Lei T, Sayed Ahmed SM, Adelsberg DC, Carreno JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative; Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F. Amanat F, et al. Among authors: thapa m. medRxiv [Preprint]. 2021 May 1:2021.03.07.21253098. doi: 10.1101/2021.03.07.21253098. medRxiv. 2021. PMID: 33758878 Free PMC article. Preprint.
A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants.
Schmitz AJ, Turner JS, Liu Z, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Alsoussi WB, Case JB, Lei T, Thapa M, Amanat F, O'Halloran JA, Shi PY, Presti RM, Krammer F, Bajic G, Whelan SPJ, Diamond MS, Boon ACM, Ellebedy AH. Schmitz AJ, et al. Among authors: thapa m. bioRxiv [Preprint]. 2021 Mar 24:2021.03.24.436864. doi: 10.1101/2021.03.24.436864. bioRxiv. 2021. Update in: Immunity. 2021 Sep 14;54(9):2159-2166.e6. doi: 10.1016/j.immuni.2021.08.013 PMID: 33791696 Free PMC article. Updated. Preprint.
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.
Turner JS, O'Halloran JA, Kalaidina E, Kim W, Schmitz AJ, Zhou JQ, Lei T, Thapa M, Chen RE, Case JB, Amanat F, Rauseo AM, Haile A, Xie X, Klebert MK, Suessen T, Middleton WD, Shi PY, Krammer F, Teefey SA, Diamond MS, Presti RM, Ellebedy AH. Turner JS, et al. Among authors: thapa m. Nature. 2021 Aug;596(7870):109-113. doi: 10.1038/s41586-021-03738-2. Epub 2021 Jun 28. Nature. 2021. PMID: 34182569 Free PMC article.
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2.
Amanat F, Thapa M, Lei T, Ahmed SMS, Adelsberg DC, Carreño JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative; Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F. Amanat F, et al. Among authors: thapa m. Cell. 2021 Jul 22;184(15):3936-3948.e10. doi: 10.1016/j.cell.2021.06.005. Epub 2021 Jun 8. Cell. 2021. PMID: 34192529 Free PMC article.
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, Demissie EG, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Pawar N, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Akuse S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. Deepak P, et al. Among authors: thapa m. Ann Intern Med. 2021 Nov;174(11):1572-1585. doi: 10.7326/M21-1757. Epub 2021 Aug 31. Ann Intern Med. 2021. PMID: 34461029 Free PMC article.
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants.
Schmitz AJ, Turner JS, Liu Z, Zhou JQ, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Altomare CG, Alsoussi WB, Case JB, VanBlargan LA, Lei T, Thapa M, Amanat F, Jeevan T, Fabrizio T, O'Halloran JA, Shi PY, Presti RM, Webby RJ, Krammer F, Whelan SPJ, Bajic G, Diamond MS, Boon ACM, Ellebedy AH. Schmitz AJ, et al. Among authors: thapa m. Immunity. 2021 Sep 14;54(9):2159-2166.e6. doi: 10.1016/j.immuni.2021.08.013. Epub 2021 Aug 17. Immunity. 2021. PMID: 34464596 Free PMC article.
Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination.
Kim W, Zhou JQ, Sturtz AJ, Horvath SC, Schmitz AJ, Lei T, Kalaidina E, Thapa M, Alsoussi WB, Haile A, Klebert MK, Suessen T, Parra-Rodriguez L, Mudd PA, Middleton WD, Teefey SA, Pusic I, O'Halloran JA, Presti RM, Turner JS, Ellebedy AH. Kim W, et al. Among authors: thapa m. bioRxiv [Preprint]. 2021 Nov 2:2021.10.31.466651. doi: 10.1101/2021.10.31.466651. bioRxiv. 2021. Update in: Nature. 2022 Apr;604(7904):141-145. doi: 10.1038/s41586-022-04527-1 PMID: 34751268 Free PMC article. Updated. Preprint.
263 results