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Page 1
Dietary spermidine improves cognitive function.
Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Müller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Üçal M, Schäfer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Tölle RC, Sótonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Rácz B, Kiechl S, Eisenberg T, Madeo F. Schroeder S, et al. Among authors: dammbrueck c. Cell Rep. 2021 Apr 13;35(2):108985. doi: 10.1016/j.celrep.2021.108985. Cell Rep. 2021. PMID: 33852843 Free article.
Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Among authors: dammbrueck c. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. Nat Med. 2016. PMID: 27841876 Free PMC article.
Dietary spermidine for lowering high blood pressure.
Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Eisenberg T, et al. Among authors: dammbrueck c. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. Autophagy. 2017. PMID: 28118075 Free PMC article.
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline.
Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A. Schwarz C, et al. Among authors: dammbrueck c. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. Aging (Albany NY). 2018. PMID: 29315079 Free PMC article. Clinical Trial.
The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. Carmona-Gutierrez D, et al. Among authors: dammbrueck c. Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w. Nat Commun. 2019. PMID: 30783116 Free PMC article.
Chemical activation of SAT1 corrects diet-induced metabolic syndrome.
Castoldi F, Hyvönen MT, Durand S, Aprahamian F, Sauvat A, Malik SA, Baracco EE, Vacchelli E, Opolon P, Signolle N, Lefevre D, Bossut N, Eisenberg T, Dammbrueck C, Pendl T, Kremer M, Lachkar S, Einer C, Michalke B, Zischka H, Madeo F, Keinänen TA, Maiuri MC, Pietrocola F, Kroemer G. Castoldi F, et al. Among authors: dammbrueck c. Cell Death Differ. 2020 Oct;27(10):2904-2920. doi: 10.1038/s41418-020-0550-z. Epub 2020 May 6. Cell Death Differ. 2020. PMID: 32376874 Free PMC article.
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity.
Ring J, Tadic J, Ristic S, Poglitsch M, Bergmann M, Radic N, Mossmann D, Liang Y, Maglione M, Jerkovic A, Hajiraissi R, Hanke M, Küttner V, Wolinski H, Zimmermann A, Domuz Trifunović L, Mikolasch L, Moretti DN, Broeskamp F, Westermayer J, Abraham C, Schauer S, Dammbrueck C, Hofer SJ, Abdellatif M, Grundmeier G, Kroemer G, Braun RJ, Hansen N, Sommer C, Ninkovic M, Seba S, Rockenfeller P, Vögtle FN, Dengjel J, Meisinger C, Keller A, Sigrist SJ, Eisenberg T, Madeo F. Ring J, et al. Among authors: dammbrueck c. EMBO Mol Med. 2022 May 9;14(5):e13952. doi: 10.15252/emmm.202113952. Epub 2022 Apr 4. EMBO Mol Med. 2022. PMID: 35373908 Free PMC article.