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The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D.
Chaikovsky AC, Li C, Jeng EE, Loebell S, Lee MC, Murray CW, Cheng R, Demeter J, Swaney DL, Chen SH, Newton BW, Johnson JR, Drainas AP, Shue YT, Seoane JA, Srinivasan P, He A, Yoshida A, Hipkins SQ, McCrea E, Poltorack CD, Krogan NJ, Diehl JA, Kong C, Jackson PK, Curtis C, Petrov DA, Bassik MC, Winslow MM, Sage J. Chaikovsky AC, et al. Among authors: lee mc. Nature. 2021 Apr;592(7856):794-798. doi: 10.1038/s41586-021-03474-7. Epub 2021 Apr 14. Nature. 2021. PMID: 33854239 Free PMC article.
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Coles GL, Cristea S, Webber JT, Levin RS, Moss SM, He A, Sangodkar J, Hwang YC, Arand J, Drainas AP, Mooney NA, Demeter J, Spradlin JN, Mauch B, Le V, Shue YT, Ko JH, Lee MC, Kong C, Nomura DK, Ohlmeyer M, Swaney DL, Krogan NJ, Jackson PK, Narla G, Gordan JD, Shokat KM, Sage J. Coles GL, et al. Among authors: lee mc. Cancer Cell. 2020 Jul 13;38(1):129-143.e7. doi: 10.1016/j.ccell.2020.05.003. Epub 2020 Jun 11. Cancer Cell. 2020. PMID: 32531271 Free PMC article.
RB depletion is required for the continuous growth of tumors initiated by loss of RB.
Doan A, Arand J, Gong D, Drainas AP, Shue YT, Lee MC, Zhang S, Walter DM, Chaikovsky AC, Feldser DM, Vogel H, Dow LE, Skotheim JM, Sage J. Doan A, et al. Among authors: lee mc. PLoS Genet. 2021 Dec 8;17(12):e1009941. doi: 10.1371/journal.pgen.1009941. eCollection 2021 Dec. PLoS Genet. 2021. PMID: 34879057 Free PMC article.
Spatial epitope barcoding reveals clonal tumor patch behaviors.
Rovira-Clavé X, Drainas AP, Jiang S, Bai Y, Baron M, Zhu B, Dallas AE, Lee MC, Chu TP, Holzem A, Ayyagari R, Bhattacharya D, McCaffrey EF, Greenwald NF, Markovic M, Coles GL, Angelo M, Bassik MC, Sage J, Nolan GP. Rovira-Clavé X, et al. Among authors: lee mc. Cancer Cell. 2022 Nov 14;40(11):1423-1439.e11. doi: 10.1016/j.ccell.2022.09.014. Epub 2022 Oct 13. Cancer Cell. 2022. PMID: 36240778 Free PMC article.
A multiplexed in vivo approach to identify driver genes in small cell lung cancer.
Lee MC, Cai H, Murray CW, Li C, Shue YT, Andrejka L, He AL, Holzem AME, Drainas AP, Ko JH, Coles GL, Kong C, Zhu S, Zhu C, Wang J, van de Rijn M, Petrov DA, Winslow MM, Sage J. Lee MC, et al. Cell Rep. 2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990. Epub 2023 Jan 13. Cell Rep. 2023. PMID: 36640300 Free PMC article.
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis.
Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, Drainas AP, Bhattacharya D, Tomasich E, Lee MC, Yang D, Kim J, Peiris-Pagès M, Simpson KL, Dive C, Preusser M, Toland A, Kong C, Das M, Winslow MM, Pasca AM, Sage J. Qu F, et al. Among authors: lee mc. Nat Cell Biol. 2023 Oct;25(10):1506-1519. doi: 10.1038/s41556-023-01241-6. Epub 2023 Oct 2. Nat Cell Biol. 2023. PMID: 37783795 Free PMC article.
2,511 results