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An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Brown JH, Peterson KL, Omens JH, McCulloch AD, Chen J. Sheikh F, et al. J Clin Invest. 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3. J Clin Invest. 2008. PMID: 19033658 Free PMC article.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Sheikh F, et al. J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426213 Free PMC article.
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. Raskin A, et al. Among authors: sheikh f. J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9. J Biol Chem. 2012. PMID: 22778266 Free PMC article.
Breaking down protein degradation mechanisms in cardiac muscle.
Lyon RC, Lange S, Sheikh F. Lyon RC, et al. Among authors: sheikh f. Trends Mol Med. 2013 Apr;19(4):239-49. doi: 10.1016/j.molmed.2013.01.005. Epub 2013 Feb 27. Trends Mol Med. 2013. PMID: 23453282 Free PMC article. Review.
489 results