Yin WC - Search Results

1

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors.

Ren PX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F. Ren PX, et al. Among authors: yin wc. Acta Pharmacol Sin. 2022 Feb;43(2):483-493. doi: 10.1038/s41401-021-00668-7. Epub 2021 Apr 27. Acta Pharmacol Sin. 2022. PMID: 33907306 Free PMC article.

2

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.

Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE. Yin W, et al. Science. 2020 Jun 26;368(6498):1499-1504. doi: 10.1126/science.abc1560. Epub 2020 May 1. Science. 2020. PMID: 32358203 Free PMC article.

3

RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19.

Jiang Y, Yin W, Xu HE. Jiang Y, et al. Biochem Biophys Res Commun. 2021 Jan 29;538:47-53. doi: 10.1016/j.bbrc.2020.08.116. Epub 2020 Sep 4. Biochem Biophys Res Commun. 2021. PMID: 32943188 Free PMC article. Review.

4

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.

Zhou Y, Fu Y, Yin W, Li J, Wang W, Bai F, Xu S, Gong Q, Peng T, Hong Y, Zhang D, Zhang D, Liu Q, Xu Y, Xu HE, Zhang H, Jiang H, Liu H. Zhou Y, et al. J Med Chem. 2021 Feb 25;64(4):1844-1855. doi: 10.1021/acs.jmedchem.0c01863. Epub 2021 Feb 11. J Med Chem. 2021. PMID: 33570950

5

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.

Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H. Yin W, et al. Nat Struct Mol Biol. 2021 Mar;28(3):319-325. doi: 10.1038/s41594-021-00570-0. Epub 2021 Mar 5. Nat Struct Mol Biol. 2021. PMID: 33674802

6

Structures of full-length glycoprotein hormone receptor signalling complexes.

Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE. Duan J, et al. Nature. 2021 Oct;598(7882):688-692. doi: 10.1038/s41586-021-03924-2. Epub 2021 Sep 22. Nature. 2021. PMID: 34552239

7

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.

Xie Y, Yin W, Zhang Y, Shang W, Wang Z, Luan X, Tian G, Aisa HA, Xu Y, Xiao G, Li J, Jiang H, Zhang S, Zhang L, Xu HE, Shen J. Xie Y, et al. Cell Res. 2021 Nov;31(11):1212-1214. doi: 10.1038/s41422-021-00570-1. Epub 2021 Sep 28. Cell Res. 2021. PMID: 34584244 Free PMC article. No abstract available.

8

Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19.

Wu CR, Yin WC, Jiang Y, Xu HE. Wu CR, et al. Among authors: yin wc. Acta Pharmacol Sin. 2022 Dec;43(12):3021-3033. doi: 10.1038/s41401-021-00851-w. Epub 2022 Jan 20. Acta Pharmacol Sin. 2022. PMID: 35058587 Free PMC article. Review.

9

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody.

Yin W, Xu Y, Xu P, Cao X, Wu C, Gu C, He X, Wang X, Huang S, Yuan Q, Wu K, Hu W, Huang Z, Liu J, Wang Z, Jia F, Xia K, Liu P, Wang X, Song B, Zheng J, Jiang H, Cheng X, Jiang Y, Deng SJ, Xu HE. Yin W, et al. Science. 2022 Mar 4;375(6584):1048-1053. doi: 10.1126/science.abn8863. Epub 2022 Feb 8. Science. 2022. PMID: 35133176 Free PMC article.

10

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors.

Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y. Duan J, et al. Nat Commun. 2022 Mar 15;13(1):1364. doi: 10.1038/s41467-022-29072-3. Nat Commun. 2022. PMID: 35292680 Free PMC article.

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