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Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA. Harb H, et al. Among authors: ploegh h. Immunity. 2021 Jun 8;54(6):1186-1199.e7. doi: 10.1016/j.immuni.2021.04.002. Epub 2021 Apr 28. Immunity. 2021. PMID: 33915108 Free PMC article.
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL. Pishesha N, et al. Among authors: ploegh hl. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7. Proc Natl Acad Sci U S A. 2017. PMID: 28270614 Free PMC article.
Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs.
Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Dougan M, et al. Among authors: ploegh hl. Cancer Immunol Res. 2018 Apr;6(4):389-401. doi: 10.1158/2326-6066.CIR-17-0495. Epub 2018 Feb 19. Cancer Immunol Res. 2018. PMID: 29459478 Free PMC article.
Nanobody-Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses.
Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL. Woodham AW, et al. Cancer Immunol Res. 2018 Jul;6(7):870-880. doi: 10.1158/2326-6066.CIR-17-0661. Epub 2018 May 23. Cancer Immunol Res. 2018. PMID: 29792298 Free PMC article.
Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.
Rashidian M, LaFleur MW, Verschoor VL, Dongre A, Zhang Y, Nguyen TH, Kolifrath S, Aref AR, Lau CJ, Paweletz CP, Bu X, Freeman GJ, Barrasa MI, Weinberg RA, Sharpe AH, Ploegh HL. Rashidian M, et al. Among authors: ploegh hl. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16971-16980. doi: 10.1073/pnas.1905005116. Epub 2019 Aug 2. Proc Natl Acad Sci U S A. 2019. PMID: 31375632 Free PMC article.
In vivo detection of antigen-specific CD8+ T cells by immuno-positron emission tomography.
Woodham AW, Zeigler SH, Zeyang EL, Kolifrath SC, Cheloha RW, Rashidian M, Chaparro RJ, Seidel RD, Garforth SJ, Dearling JL, Mesyngier M, Duddempudi PK, Packard AB, Almo SC, Ploegh HL. Woodham AW, et al. Among authors: ploegh hl. Nat Methods. 2020 Oct;17(10):1025-1032. doi: 10.1038/s41592-020-0934-5. Epub 2020 Sep 14. Nat Methods. 2020. PMID: 32929269 Free PMC article.
641 results