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Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential.
Carruthers LV, Munday JC, Ebiloma GU, Steketee P, Jayaraman S, Campagnaro GD, Ungogo MA, Lemgruber L, Donachie AM, Rowan TG, Peter R, Morrison LJ, Barrett MP, De Koning HP. Carruthers LV, et al. Among authors: lemgruber l. Mol Microbiol. 2021 Aug;116(2):564-588. doi: 10.1111/mmi.14733. Epub 2021 May 18. Mol Microbiol. 2021. PMID: 33932053 Free article.
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.
Millan CR, Acosta-Reyes FJ, Lagartera L, Ebiloma GU, Lemgruber L, Nué Martínez JJ, Saperas N, Dardonville C, de Koning HP, Campos JL. Millan CR, et al. Among authors: lemgruber l. Nucleic Acids Res. 2017 Aug 21;45(14):8378-8391. doi: 10.1093/nar/gkx521. Nucleic Acids Res. 2017. PMID: 28637278 Free PMC article.
Discovery of Sustainable Drugs for Neglected Tropical Diseases: Cashew Nut Shell Liquid (CNSL)-Based Hybrids Target Mitochondrial Function and ATP Production in Trypanosoma brucei.
Cerone M, Uliassi E, Prati F, Ebiloma GU, Lemgruber L, Bergamini C, Watson DG, de A M Ferreira T, Roth Cardoso GSH, Soares Romeiro LA, de Koning HP, Bolognesi ML. Cerone M, et al. Among authors: lemgruber l. ChemMedChem. 2019 Mar 22;14(6):621-635. doi: 10.1002/cmdc.201800790. Epub 2019 Feb 5. ChemMedChem. 2019. PMID: 30664325 Free PMC article.
Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase.
Cueto-Díaz EJ, Ebiloma GU, Alfayez IA, Ungogo MA, Lemgruber L, González-García MC, Giron MD, Salto R, Fueyo-González FJ, Shiba T, González-Vera JA, Ruedas Rama MJ, Orte A, de Koning HP, Dardonville C. Cueto-Díaz EJ, et al. Among authors: lemgruber l. Eur J Med Chem. 2021 Aug 5;220:113470. doi: 10.1016/j.ejmech.2021.113470. Epub 2021 Apr 16. Eur J Med Chem. 2021. PMID: 33940464 Free article.
Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites.
Robertson J, Ungogo MA, Aldfer MM, Lemgruber L, McWhinnie FS, Bode BE, Jones KL, Watson AJB, de Koning HP, Burley GA. Robertson J, et al. Among authors: lemgruber l. ChemMedChem. 2021 Nov 19;16(22):3396-3401. doi: 10.1002/cmdc.202100509. Epub 2021 Sep 2. ChemMedChem. 2021. PMID: 34357687 Free PMC article.
59 results