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MHC Class II Antigen Presentation by Lymphatic Endothelial Cells in Tumors Promotes Intratumoral Regulatory T cell-Suppressive Functions.
Gkountidi AO, Garnier L, Dubrot J, Angelillo J, Harlé G, Brighouse D, Wrobel LJ, Pick R, Scheiermann C, Swartz MA, Hugues S. Gkountidi AO, et al. Among authors: brighouse d. Cancer Immunol Res. 2021 Jul;9(7):748-764. doi: 10.1158/2326-6066.CIR-20-0784. Epub 2021 May 5. Cancer Immunol Res. 2021. PMID: 33952631 Free PMC article.
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Garnier L, Pick R, Montorfani J, Sun M, Brighouse D, Liaudet N, Kammertoens T, Blankenstein T, Page N, Bernier-Latamani J, Tran NL, Petrova TV, Merkler D, Scheiermann C, Hugues S. Garnier L, et al. Among authors: brighouse d. Sci Adv. 2022 Jun 10;8(23):eabl5162. doi: 10.1126/sciadv.abl5162. Epub 2022 Jun 8. Sci Adv. 2022. PMID: 35675399 Free PMC article.
IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.
Lippens C, Duraes FV, Dubrot J, Brighouse D, Lacroix M, Irla M, Aubry-Lachainaye JP, Reith W, Mandl JN, Hugues S. Lippens C, et al. Among authors: brighouse d. J Autoimmun. 2016 Dec;75:39-49. doi: 10.1016/j.jaut.2016.07.004. Epub 2016 Jul 26. J Autoimmun. 2016. PMID: 27470005 Free PMC article.
Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.
Dubrot J, Duraes FV, Harlé G, Schlaeppi A, Brighouse D, Madelon N, Göpfert C, Stokar-Regenscheit N, Acha-Orbea H, Reith W, Gannagé M, Hugues S. Dubrot J, et al. Among authors: brighouse d. Life Sci Alliance. 2018 Dec 17;1(6):e201800164. doi: 10.26508/lsa.201800164. eCollection 2018 Dec. Life Sci Alliance. 2018. PMID: 30584641 Free PMC article.
33 results