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Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis.
Harris C, Xu W, Grassi L, Wang C, Markle A, Hardman C, Stevens R, Miro-Quesada G, Hatton D, Wang J. Harris C, et al. Among authors: hardman c. MAbs. 2019 Nov-Dec;11(8):1452-1463. doi: 10.1080/19420862.2019.1667740. Epub 2019 Oct 1. MAbs. 2019. PMID: 31570042 Free PMC article.
Engineering the expression of an anti-interleukin-13 antibody through rational design and mutagenesis.
Popovic B, Gibson S, Senussi T, Carmen S, Kidd S, Slidel T, Strickland I, Jianqing X, Spooner J, Lewis A, Hudson N, Mackenzie L, Keen J, Kemp B, Hardman C, Hatton D, Wilkinson T, Vaughan T, Lowe D. Popovic B, et al. Among authors: hardman c. Protein Eng Des Sel. 2017 Apr 1;30(4):303-311. doi: 10.1093/protein/gzx001. Protein Eng Des Sel. 2017. PMID: 28130326
Haplosaurus computes protein haplotypes for use in precision drug design.
Spooner W, McLaren W, Slidel T, Finch DK, Butler R, Campbell J, Eghobamien L, Rider D, Kiefer CM, Robinson MJ, Hardman C, Cunningham F, Vaughan T, Flicek P, Huntington CC. Spooner W, et al. Among authors: hardman c. Nat Commun. 2018 Oct 8;9(1):4128. doi: 10.1038/s41467-018-06542-1. Nat Commun. 2018. PMID: 30297836 Free PMC article.
Backbone dynamics of the A-domain of HMG1 as studied by 15N NMR spectroscopy.
Broadhurst RW, Hardman CH, Thomas JO, Laue ED. Broadhurst RW, et al. Among authors: hardman ch. Biochemistry. 1995 Dec 26;34(51):16608-17. doi: 10.1021/bi00051a008. Biochemistry. 1995. PMID: 8527433
HMG1 has two such boxes, A and B, which show approximately 30% sequence identity, and an acidic C-terminal tail. The boxes are responsible for the ability of the protein to bend DNA and bind to bent or distorted DNA. ...By estimating the angle between the amide bond vector …
HMG1 has two such boxes, A and B, which show approximately 30% sequence identity, and an acidic C-terminal tail. The boxes are respon …
259 results