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Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.
Liu TC, Kern JT, Jain U, Sonnek NM, Xiong S, Simpson KF, VanDussen KL, Winkler ES, Haritunians T, Malique A, Lu Q, Sasaki Y, Storer C, Diamond MS, Head RD, McGovern DPB, Stappenbeck TS. Liu TC, et al. Among authors: jain u. Cell Host Microbe. 2021 Jun 9;29(6):988-1001.e6. doi: 10.1016/j.chom.2021.04.004. Epub 2021 May 18. Cell Host Microbe. 2021. PMID: 34010595 Free PMC article.
PAI-1 augments mucosal damage in colitis.
Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirović A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS. Kaiko GE, et al. Among authors: jain u. Sci Transl Med. 2019 Mar 6;11(482):eaat0852. doi: 10.1126/scitranslmed.aat0852. Sci Transl Med. 2019. PMID: 30842312 Free PMC article.
Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice.
Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS. Jain U, et al. Science. 2021 Mar 12;371(6534):1154-1159. doi: 10.1126/science.abd0919. Science. 2021. PMID: 33707263 Free PMC article.
312 results