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Page 1
Discovery of electrophilic degraders that exploit SNAr chemistry.
Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Słabicki M, Fischer ES, Ebert BL, Gray NS. Zhuang Z, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.615094. doi: 10.1101/2024.09.25.615094. bioRxiv. 2024. PMID: 39386645 Free PMC article. Preprint.
A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development.
Fan AT, Gadbois GE, Huang HT, Jiang J, Sigua LH, Smith ER, Wu S, Dunne-Dombrink K, Goyal P, Tao AJ, Sellers W, Fischer ES, Donovan KA, Ferguson FM. Fan AT, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Sep 21:2024.09.17.612508. doi: 10.1101/2024.09.17.612508. bioRxiv. 2024. PMID: 39345570 Free PMC article. Preprint.
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. Among authors: fischer es. Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904. Epub 2024 Sep 24. Eur J Med Chem. 2024. PMID: 39341093 Free article.
Unveiling the hidden interactome of CRBN molecular glues with chemoproteomics.
Baek K, Metivier RJ, Roy Burman SS, Bushman JW, Yoon H, Lumpkin RJ, Abeja DM, Lakshminarayan M, Yue H, Ojeda S, Verano AL, Gray NS, Donovan KA, Fischer ES. Baek K, et al. Among authors: fischer es. bioRxiv [Preprint]. 2024 Oct 4:2024.09.11.612438. doi: 10.1101/2024.09.11.612438. bioRxiv. 2024. PMID: 39314457 Free PMC article. Preprint.
Discovery of Potent Degraders of the Dengue Virus Envelope Protein.
Li Z, Liu HY, He Z, Chakravarty A, Golden RP, Jiang Z, You I, Yue H, Donovan KA, Du G, Che J, Tse J, Che I, Lu W, Fischer ES, Zhang T, Gray NS, Yang PL. Li Z, et al. Among authors: fischer es. Adv Sci (Weinh). 2024 Oct;11(40):e2405829. doi: 10.1002/advs.202405829. Epub 2024 Aug 15. Adv Sci (Weinh). 2024. PMID: 39145423 Free PMC article.
130 results