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STEP® vectors for rapid generation of stable transfected CHO cell pools and clones with high expression levels and product quality homogeneity of difficult-to-express proteins.
Luthra A, Spanjaard RA, Cheema S, Veith N, Kober L, Wang Y, Jing T, Zhao Y, Hoeksema F, Yallop C, Havenga M, Bakker WAM. Luthra A, et al. Among authors: hoeksema f. Protein Expr Purif. 2021 Oct;186:105920. doi: 10.1016/j.pep.2021.105920. Epub 2021 May 25. Protein Expr Purif. 2021. PMID: 34044134 Free article.
Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery.
Kumar P, Pullagurla SR, Patel A, Shukla RS, Bird C, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Joshi SB, Volkin DB. Kumar P, et al. Among authors: hoeksema f. J Pharm Sci. 2021 Feb;110(2):760-770. doi: 10.1016/j.xphs.2020.09.047. Epub 2020 Oct 7. J Pharm Sci. 2021. PMID: 33035539 Free PMC article.
Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries.
Kumar P, Shukla RS, Patel A, Pullagurla SR, Bird C, Ogun O, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Joshi SB, Volkin DB. Kumar P, et al. Among authors: hoeksema f. Hum Vaccin Immunother. 2021 Jul 3;17(7):2298-2310. doi: 10.1080/21645515.2021.1885279. Epub 2021 Apr 16. Hum Vaccin Immunother. 2021. PMID: 33861183 Free PMC article.
Modeling the long-term 2-8 °C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and accelerated stability data.
Pullagurla SR, Kumar P, Ogun O, Kumru OS, Hamidi A, Hoeksema F, Yallop C, Bines JE, Volkin DB, Joshi SB. Pullagurla SR, et al. Among authors: hoeksema f. Biologicals. 2022 Jan;75:21-28. doi: 10.1016/j.biologicals.2021.12.001. Epub 2021 Dec 17. Biologicals. 2022. PMID: 34924260 Free article.