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A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Jenkins LJ, Poh AR, Walkiewicz M, Leong T, Mariadason JM, Cebon J, Balachander SB, Cidado JR, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: jenkins lj. Cell Death Discov. 2021 May 28;7(1):122. doi: 10.1038/s41420-021-00505-0. Cell Death Discov. 2021. PMID: 34050131 Free PMC article.
ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.
Chüeh AC, Tse JWT, Dickinson M, Ioannidis P, Jenkins L, Togel L, Tan B, Luk I, Davalos-Salas M, Nightingale R, Thompson MR, Williams BRG, Lessene G, Lee EF, Fairlie WD, Dhillon AS, Mariadason JM. Chüeh AC, et al. Clin Cancer Res. 2017 Sep 15;23(18):5573-5584. doi: 10.1158/1078-0432.CCR-17-0466. Epub 2017 Jun 13. Clin Cancer Res. 2017. PMID: 28611196 Free PMC article.
Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets.
Lau DK, Mouradov D, Wasenang W, Luk IY, Scott CM, Williams DS, Yeung YH, Limpaiboon T, Iatropoulos GF, Jenkins LJ, Reehorst CM, Chionh F, Nikfarjam M, Croagh D, Dhillon AS, Weickhardt AJ, Muramatsu T, Saito Y, Tebbutt NC, Sieber OM, Mariadason JM. Lau DK, et al. Among authors: jenkins lj. iScience. 2019 Nov 22;21:624-637. doi: 10.1016/j.isci.2019.10.044. Epub 2019 Oct 31. iScience. 2019. PMID: 31731200 Free PMC article.
BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: jenkins lj. Cell Death Discov. 2020 Oct 31;6(1):114. doi: 10.1038/s41420-020-00348-1. Cell Death Discov. 2020. PMID: 33298868 Free PMC article.
Rapid Resistance of FGFR-driven Gastric Cancers to Regorafenib and Targeted FGFR Inhibitors can be Overcome by Parallel Inhibition of MEK.
Lau DK, Luk IY, Jenkins LJ, Martin A, Williams DS, Schoffer KL, Chionh F, Buchert M, Sjoquist K, Boussioutas A, Hayes SA, Ernst M, Weickhardt AJ, Pavlakis N, Tebbutt NC, Mariadason JM. Lau DK, et al. Among authors: jenkins lj. Mol Cancer Ther. 2021 Apr;20(4):704-715. doi: 10.1158/1535-7163.MCT-20-0836. Epub 2021 Feb 9. Mol Cancer Ther. 2021. PMID: 33563752 Clinical Trial.
Correction: BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.
Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, Lee EF, John T, Fairlie WD. Arulananda S, et al. Among authors: jenkins lj. Cell Death Discov. 2021 Jun 15;7(1):146. doi: 10.1038/s41420-020-00388-7. Cell Death Discov. 2021. PMID: 34131107 Free PMC article. No abstract available.
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis.
Reehorst CM, Nightingale R, Luk IY, Jenkins L, Koentgen F, Williams DS, Darido C, Tan F, Anderton H, Chopin M, Schoffer K, Eissmann MF, Buchert M, Mouradov D, Sieber OM, Ernst M, Dhillon AS, Mariadason JM. Reehorst CM, et al. Development. 2021 Jun 15;148(12):dev199542. doi: 10.1242/dev.199542. Epub 2021 Jun 28. Development. 2021. PMID: 34180969
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