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Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota.
Zeng W, Wu AG, Zhou XG, Khan I, Zhang RL, Lo HH, Qu LQ, Song LL, Yun XY, Wang HM, Chen J, Ng JPL, Ren F, Yuan SY, Yu L, Tang Y, Huang GX, Wong VKW, Chung SK, Mok SWF, Qin DL, Sun HL, Liu L, Hsiao WLW, Law BYK. Zeng W, et al. Among authors: chen j. Pharmacol Res. 2021 Aug;170:105697. doi: 10.1016/j.phrs.2021.105697. Epub 2021 May 29. Pharmacol Res. 2021. PMID: 34062240
SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.
Xu SW, Law BYK, Qu SLQ, Hamdoun S, Chen J, Zhang W, Guo JR, Wu AG, Mok SWF, Zhang DW, Xia C, Sugimoto Y, Efferth T, Liu L, Wong VKW. Xu SW, et al. Among authors: chen j. Pharmacol Res. 2020 Mar;153:104660. doi: 10.1016/j.phrs.2020.104660. Epub 2020 Jan 23. Pharmacol Res. 2020. PMID: 31982489
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.
Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J. Ren JH, et al. Among authors: chen j, chen wx. Hepatology. 2018 Oct;68(4):1260-1276. doi: 10.1002/hep.29912. Epub 2018 Jul 25. Hepatology. 2018. PMID: 29624717
A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A.
Zhou L, Ren JH, Cheng ST, Xu HM, Chen WX, Chen DP, Wong VKW, Law BYK, Liu Y, Cai XF, Tang H, Yu HB, Hu JL, Hu Y, Zhou HZ, Ren F, He L, Hu ZW, Jiang H, Xu HY, Huang AL, Chen J. Zhou L, et al. Among authors: chen j, chen wx, chen dp. Hepatology. 2019 May;69(5):1885-1902. doi: 10.1002/hep.30497. Epub 2019 Mar 15. Hepatology. 2019. PMID: 30614547
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