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Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates.
Martin JT, Hartwell BL, Kumarapperuma SC, Melo MB, Carnathan DG, Cossette BJ, Adams J, Gong S, Zhang W, Tokatlian T, Menis S, Schiffner T, Franklin CG, Goins B, Fox PT, Silvestri G, Schief WR, Ruprecht RM, Irvine DJ. Martin JT, et al. Among authors: ruprecht rm. Biomaterials. 2021 Aug;275:120868. doi: 10.1016/j.biomaterials.2021.120868. Epub 2021 May 14. Biomaterials. 2021. PMID: 34091299 Free PMC article.
PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure.
Taylor RA, Xiao S, Carias AM, McRaven MD, Thakkar DN, Araínga M, Allen EJ, Rogers KA, Kumarapperuma SC, Gong S, Fought AJ, Anderson MR, Thomas Y, Schneider JR, Goins B, Fox P, Villinger FJ, Ruprecht RM, Hope TJ. Taylor RA, et al. Among authors: ruprecht rm. PLoS Pathog. 2021 Jun 1;17(6):e1009632. doi: 10.1371/journal.ppat.1009632. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34061907 Free PMC article.
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity.
Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ. Silva M, et al. Among authors: ruprecht rm. Sci Immunol. 2021 Dec 3;6(66):eabf1152. doi: 10.1126/sciimmunol.abf1152. Epub 2021 Dec 3. Sci Immunol. 2021. PMID: 34860581 Free PMC article.
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity.
Hartwell BL, Melo MB, Xiao P, Lemnios AA, Li N, Chang JYH, Yu J, Gebre MS, Chang A, Maiorino L, Carter C, Moyer TJ, Dalvie NC, Rodriguez-Aponte SA, Rodrigues KA, Silva M, Suh H, Adams J, Fontenot J, Love JC, Barouch DH, Villinger F, Ruprecht RM, Irvine DJ. Hartwell BL, et al. Among authors: ruprecht rm. Sci Transl Med. 2022 Jul 20;14(654):eabn1413. doi: 10.1126/scitranslmed.abn1413. Epub 2022 Jul 20. Sci Transl Med. 2022. PMID: 35857825 Free PMC article.
Immunoglobulin M: An Ancient Antiviral Weapon - Rediscovered.
Gong S, Ruprecht RM. Gong S, et al. Among authors: ruprecht rm. Front Immunol. 2020 Aug 11;11:1943. doi: 10.3389/fimmu.2020.01943. eCollection 2020. Front Immunol. 2020. PMID: 32849652 Free PMC article. Review.
No acquisition: a new ambition for HIV vaccine development?
Lakhashe SK, Silvestri G, Ruprecht RM. Lakhashe SK, et al. Among authors: ruprecht rm. Curr Opin Virol. 2011 Oct;1(4):246-53. doi: 10.1016/j.coviro.2011.07.005. Curr Opin Virol. 2011. PMID: 22081778 Free PMC article. Review.
Cooperation Between Systemic IgG1 and Mucosal Dimeric IgA2 Monoclonal Anti-HIV Env Antibodies: Passive Immunization Protects Indian Rhesus Macaques Against Mucosal SHIV Challenges.
Gong S, Lakhashe SK, Hariraju D, Scinto H, Lanzavecchia A, Cameroni E, Corti D, Ratcliffe SJ, Rogers KA, Xiao P, Fontenot J, Villinger F, Ruprecht RM. Gong S, et al. Among authors: ruprecht rm. Front Immunol. 2021 Aug 3;12:705592. doi: 10.3389/fimmu.2021.705592. eCollection 2021. Front Immunol. 2021. PMID: 34413855 Free PMC article.
Anti-HIV IgM protects against mucosal SHIV transmission.
Gong S, Tomusange K, Kulkarni V, Adeniji OS, Lakhashe SK, Hariraju D, Strickland A, Plake E, Frost PA, Ratcliffe SJ, Wang L, Lafer EM, Ruprecht RM. Gong S, et al. Among authors: ruprecht rm. AIDS. 2018 Jul 17;32(11):F5-F13. doi: 10.1097/QAD.0000000000001857. AIDS. 2018. PMID: 29762161 Free PMC article.
Cooperation Between Systemic and Mucosal Antibodies Induced by Virosomal Vaccines Targeting HIV-1 Env: Protection of Indian Rhesus Macaques Against Low-Dose Intravaginal SHIV Challenges.
Lakhashe SK, Amacker M, Hariraju D, Vyas HK, Morrison KS, Weiner JA, Ackerman ME, Roy V, Alter G, Ferrari G, Montefiori DC, Tomaras GD, Sawant S, Yates NL, Gast C, Fleury S, Ruprecht RM. Lakhashe SK, et al. Among authors: ruprecht rm. Front Immunol. 2022 Feb 22;13:788619. doi: 10.3389/fimmu.2022.788619. eCollection 2022. Front Immunol. 2022. PMID: 35273592 Free PMC article.
205 results