Poynton FE - Search Results

1

Understanding the factors controlling the photo-oxidation of natural DNA by enantiomerically pure intercalating ruthenium polypyridyl complexes through TA/TRIR studies with polydeoxynucleotides and mixed sequence oligodeoxynucleotides.

Keane PM, O'Sullivan K, Poynton FE, Poulsen BC, Sazanovich IV, Towrie M, Cardin CJ, Sun XZ, George MW, Gunnlaugsson T, Quinn SJ, Kelly JM. Keane PM, et al. Among authors: poynton fe. Chem Sci. 2020 Aug 6;11(32):8600-8609. doi: 10.1039/d0sc02413a. Chem Sci. 2020. PMID: 34123120 Free PMC article.

2

Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases.

Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T. Murphy S, et al. Among authors: poynton fe. Org Biomol Chem. 2014 Sep 14;12(34):6610-23. doi: 10.1039/c3ob42213e. Org Biomol Chem. 2014. PMID: 24983824

3

Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells.

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC. Cloonan SM, et al. Among authors: poynton fe. J Med Chem. 2015 Jun 11;58(11):4494-505. doi: 10.1021/acs.jmedchem.5b00451. Epub 2015 May 27. J Med Chem. 2015. PMID: 25961430

4

Reversal of a Single Base-Pair Step Controls Guanine Photo-Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex.

Keane PM, Poynton FE, Hall JP, Sazanovich IV, Towrie M, Gunnlaugsson T, Quinn SJ, Cardin CJ, Kelly JM. Keane PM, et al. Among authors: poynton fe. Angew Chem Int Ed Engl. 2015 Jul 13;54(29):8364-8. doi: 10.1002/anie.201502608. Epub 2015 Jun 11. Angew Chem Int Ed Engl. 2015. PMID: 26096623 Free PMC article.

5

Enantiomeric Conformation Controls Rate and Yield of Photoinduced Electron Transfer in DNA Sensitized by Ru(II) Dipyridophenazine Complexes.

Keane PM, Poynton FE, Hall JP, Clark IP, Sazanovich IV, Towrie M, Gunnlaugsson T, Quinn SJ, Cardin CJ, Kelly JM. Keane PM, et al. Among authors: poynton fe. J Phys Chem Lett. 2015 Feb 19;6(4):734-8. doi: 10.1021/jz502743q. Epub 2015 Feb 9. J Phys Chem Lett. 2015. PMID: 26262495

6

Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(II)-polypyridyl conjugates.

Ryan GJ, Poynton FE, Elmes RB, Erby M, Williams DC, Quinn SJ, Gunnlaugsson T. Ryan GJ, et al. Among authors: poynton fe. Dalton Trans. 2015 Oct 7;44(37):16332-44. doi: 10.1039/c5dt00360a. Dalton Trans. 2015. PMID: 26305507

7

Monitoring guanine photo-oxidation by enantiomerically resolved Ru(II) dipyridophenazine complexes using inosine-substituted oligonucleotides.

Keane PM, Poynton FE, Hall JP, Clark IP, Sazanovich IV, Towrie M, Gunnlaugsson T, Quinn SJ, Cardin CJ, Kelly JM. Keane PM, et al. Among authors: poynton fe. Faraday Discuss. 2015;185:455-69. doi: 10.1039/c5fd00085h. Faraday Discuss. 2015. PMID: 26426601

8

Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy.

Hall JP, Poynton FE, Keane PM, Gurung SP, Brazier JA, Cardin DJ, Winter G, Gunnlaugsson T, Sazanovich IV, Towrie M, Cardin CJ, Kelly JM, Quinn SJ. Hall JP, et al. Among authors: poynton fe. Nat Chem. 2015 Dec;7(12):961-7. doi: 10.1038/nchem.2369. Epub 2015 Oct 19. Nat Chem. 2015. PMID: 26587711

9

Inosine Can Increase DNA's Susceptibility to Photo-oxidation by a Ru^II Complex due to Structural Change in the Minor Groove.

Keane PM, Hall JP, Poynton FE, Poulsen BC, Gurung SP, Clark IP, Sazanovich IV, Towrie M, Gunnlaugsson T, Quinn SJ, Cardin CJ, Kelly JM. Keane PM, et al. Among authors: poynton fe. Chemistry. 2017 Aug 1;23(43):10344-10351. doi: 10.1002/chem.201701447. Epub 2017 Jul 12. Chemistry. 2017. PMID: 28543779

10

The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.

Poynton FE, Bright SA, Blasco S, Williams DC, Kelly JM, Gunnlaugsson T. Poynton FE, et al. Chem Soc Rev. 2017 Dec 11;46(24):7706-7756. doi: 10.1039/c7cs00680b. Chem Soc Rev. 2017. PMID: 29177281 Review.

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