Blankenfeldt W - Search Results

1

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.

Schütz C, Ho DK, Hamed MM, Abdelsamie AS, Röhrig T, Herr C, Kany AM, Rox K, Schmelz S, Siebenbürger L, Wirth M, Börger C, Yahiaoui S, Bals R, Scrima A, Blankenfeldt W, Horstmann JC, Christmann R, Murgia X, Koch M, Berwanger A, Loretz B, Hirsch AKH, Hartmann RW, Lehr CM, Empting M. Schütz C, et al. Among authors: blankenfeldt w. Adv Sci (Weinh). 2021 Jun;8(12):e2004369. doi: 10.1002/advs.202004369. Epub 2021 Mar 18. Adv Sci (Weinh). 2021. PMID: 34165899 Free PMC article.

2

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.

Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M, Hartmann RW. Zender M, et al. Among authors: blankenfeldt w. ACS Chem Biol. 2016 Jun 17;11(6):1755-63. doi: 10.1021/acschembio.6b00156. Epub 2016 Apr 28. ACS Chem Biol. 2016. PMID: 27082157

3

The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.

Bock T, Volz C, Hering V, Scrima A, Müller R, Blankenfeldt W. Bock T, et al. Among authors: blankenfeldt w. Nucleic Acids Res. 2017 Feb 28;45(4):2166-2178. doi: 10.1093/nar/gkw1238. Nucleic Acids Res. 2017. PMID: 27940564 Free PMC article.

4

The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC.

Witzgall F, Depke T, Hoffmann M, Empting M, Brönstrup M, Müller R, Blankenfeldt W. Witzgall F, et al. Among authors: blankenfeldt w. Chembiochem. 2018 Jul 16;19(14):1531-1544. doi: 10.1002/cbic.201800153. Epub 2018 Jun 22. Chembiochem. 2018. PMID: 29722462

5

Destructive twisting of neutral metalloproteases: the catalysis mechanism of the Dispase autolysis-inducing protein from Streptomyces mobaraensis DSM 40487.

Fiebig D, Storka J, Roeder M, Meyners C, Schmelz S, Blankenfeldt W, Scrima A, Kolmar H, Fuchsbauer HL. Fiebig D, et al. Among authors: blankenfeldt w. FEBS J. 2018 Nov;285(22):4246-4264. doi: 10.1111/febs.14647. Epub 2018 Sep 17. FEBS J. 2018. PMID: 30171661 Free article.

6

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.

Zender M, Witzgall F, Kiefer A, Kirsch B, Maurer CK, Kany AM, Xu N, Schmelz S, Börger C, Blankenfeldt W, Empting M. Zender M, et al. Among authors: blankenfeldt w. ChemMedChem. 2020 Jan 17;15(2):188-194. doi: 10.1002/cmdc.201900621. Epub 2019 Nov 28. ChemMedChem. 2020. PMID: 31709767 Free PMC article.

7

Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation.

Scheithauer L, Thiem S, Schmelz S, Dellmann A, Büssow K, Brouwer RMHJ, Ünal CM, Blankenfeldt W, Steinert M. Scheithauer L, et al. Among authors: blankenfeldt w. Cell Microbiol. 2021 May;23(5):e13313. doi: 10.1111/cmi.13313. Epub 2021 Feb 10. Cell Microbiol. 2021. PMID: 33491325

8

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.

Schütz C, Hodzic A, Hamed M, Abdelsamie AS, Kany AM, Bauer M, Röhrig T, Schmelz S, Scrima A, Blankenfeldt W, Empting M. Schütz C, et al. Among authors: blankenfeldt w. Eur J Med Chem. 2021 Dec 15;226:113797. doi: 10.1016/j.ejmech.2021.113797. Epub 2021 Aug 28. Eur J Med Chem. 2021. PMID: 34520957

9

Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.

Borgert SR, Henke S, Witzgall F, Schmelz S, Zur Lage S, Hotop SK, Stephen S, Lübken D, Krüger J, Gomez NO, van Ham M, Jänsch L, Kalesse M, Pich A, Brönstrup M, Häussler S, Blankenfeldt W. Borgert SR, et al. Among authors: blankenfeldt w. Nat Commun. 2022 Dec 1;13(1):7402. doi: 10.1038/s41467-022-35030-w. Nat Commun. 2022. PMID: 36456567 Free PMC article.

10

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.

Hamed MM, Abdelsamie AS, Rox K, Schütz C, Kany AM, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña JM, Jahn D, Rademacher J, Ringshausen FC, Cramer N, Tümmler B, Hirsch AKH, Hartmann RW, Empting M. Hamed MM, et al. Among authors: blankenfeldt w. Adv Sci (Weinh). 2023 Feb;10(5):e2204443. doi: 10.1002/advs.202204443. Epub 2023 Jan 3. Adv Sci (Weinh). 2023. PMID: 36596691 Free PMC article.

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