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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
Schütz C, Ho DK, Hamed MM, Abdelsamie AS, Röhrig T, Herr C, Kany AM, Rox K, Schmelz S, Siebenbürger L, Wirth M, Börger C, Yahiaoui S, Bals R, Scrima A, Blankenfeldt W, Horstmann JC, Christmann R, Murgia X, Koch M, Berwanger A, Loretz B, Hirsch AKH, Hartmann RW, Lehr CM, Empting M. Schütz C, et al. Among authors: hirsch akh. Adv Sci (Weinh). 2021 Jun;8(12):e2004369. doi: 10.1002/advs.202004369. Epub 2021 Mar 18. Adv Sci (Weinh). 2021. PMID: 34165899 Free PMC article.
Targeting the Plasmodium falciparum IspE Enzyme.
Diamanti E, Steinbach AM, de Carvalho LP, Ropponen HK, Lacour A, Hamid R, Eisa S, Bravo P, Bousis S, Illarionov B, Fischer M, Hamed MM, Bach NC, Rottmann M, Held J, Witschel M, Sieber SA, Hirsch AKH. Diamanti E, et al. Among authors: hirsch akh. ACS Omega. 2024 Oct 25;9(44):44465-44473. doi: 10.1021/acsomega.4c06038. eCollection 2024 Nov 5. ACS Omega. 2024. PMID: 39524657 Free PMC article.
Targeting Plasmodium falciparum IspD in the Methyl-d-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity.
Willocx D, Bizzarri L, Alhayek A, Kannan D, Bravo P, Illarionov B, Rox K, Lohse J, Fischer M, Kany AM, Hahne H, Rottmann M, Witschel M, Odom John A, Hamed MM, Diamanti E, Hirsch AKH. Willocx D, et al. Among authors: hirsch akh. J Med Chem. 2024 Oct 10;67(19):17070-17086. doi: 10.1021/acs.jmedchem.4c00212. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303294 Free PMC article.
163 results