Kany AM - Search Results

1

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.

Schütz C, Ho DK, Hamed MM, Abdelsamie AS, Röhrig T, Herr C, Kany AM, Rox K, Schmelz S, Siebenbürger L, Wirth M, Börger C, Yahiaoui S, Bals R, Scrima A, Blankenfeldt W, Horstmann JC, Christmann R, Murgia X, Koch M, Berwanger A, Loretz B, Hirsch AKH, Hartmann RW, Lehr CM, Empting M. Schütz C, et al. Among authors: kany am. Adv Sci (Weinh). 2021 Jun;8(12):e2004369. doi: 10.1002/advs.202004369. Epub 2021 Mar 18. Adv Sci (Weinh). 2021. PMID: 34165899 Free PMC article.

2

Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.

Schönauer E, Kany AM, Haupenthal J, Hüsecken K, Hoppe IJ, Voos K, Yahiaoui S, Elsässer B, Ducho C, Brandstetter H, Hartmann RW. Schönauer E, et al. Among authors: kany am. J Am Chem Soc. 2017 Sep 13;139(36):12696-12703. doi: 10.1021/jacs.7b06935. Epub 2017 Aug 31. J Am Chem Soc. 2017. PMID: 28820255 Free PMC article.

3

Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.

Kany AM, Sikandar A, Haupenthal J, Yahiaoui S, Maurer CK, Proschak E, Köhnke J, Hartmann RW. Kany AM, et al. ACS Infect Dis. 2018 Jun 8;4(6):988-997. doi: 10.1021/acsinfecdis.8b00010. Epub 2018 Mar 6. ACS Infect Dis. 2018. PMID: 29485268

4

Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.

Kany AM, Sikandar A, Yahiaoui S, Haupenthal J, Walter I, Empting M, Köhnke J, Hartmann RW. Kany AM, et al. ACS Chem Biol. 2018 Sep 21;13(9):2449-2455. doi: 10.1021/acschembio.8b00257. Epub 2018 Aug 24. ACS Chem Biol. 2018. PMID: 30088919 Free article.

5

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.

Zender M, Witzgall F, Kiefer A, Kirsch B, Maurer CK, Kany AM, Xu N, Schmelz S, Börger C, Blankenfeldt W, Empting M. Zender M, et al. Among authors: kany am. ChemMedChem. 2020 Jan 17;15(2):188-194. doi: 10.1002/cmdc.201900621. Epub 2019 Nov 28. ChemMedChem. 2020. PMID: 31709767 Free PMC article.

6

N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.

Konstantinović J, Yahiaoui S, Alhayek A, Haupenthal J, Schönauer E, Andreas A, Kany AM, Müller R, Koehnke J, Berger FK, Bischoff M, Hartmann RW, Brandstetter H, Hirsch AKH. Konstantinović J, et al. Among authors: kany am. J Med Chem. 2020 Aug 13;63(15):8359-8368. doi: 10.1021/acs.jmedchem.0c00584. Epub 2020 Jun 17. J Med Chem. 2020. PMID: 32470298 Free PMC article.

7

Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.

Murgia X, Kany AM, Herr C, Ho DK, De Rossi C, Bals R, Lehr CM, Hirsch AKH, Hartmann RW, Empting M, Röhrig T. Murgia X, et al. Among authors: kany am. Sci Rep. 2020 Oct 5;10(1):16502. doi: 10.1038/s41598-020-73459-5. Sci Rep. 2020. PMID: 33020513 Free PMC article.

8

Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.

Walter I, Adam S, Gentilini MV, Kany AM, Brengel C, Thomann A, Sparwasser T, Köhnke J, Hartmann RW. Walter I, et al. Among authors: kany am. ChemMedChem. 2021 Sep 16;16(18):2786-2801. doi: 10.1002/cmdc.202100283. Epub 2021 Jun 22. ChemMedChem. 2021. PMID: 34010508 Free PMC article.

9

Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.

Schütz C, Hodzic A, Hamed M, Abdelsamie AS, Kany AM, Bauer M, Röhrig T, Schmelz S, Scrima A, Blankenfeldt W, Empting M. Schütz C, et al. Among authors: kany am. Eur J Med Chem. 2021 Dec 15;226:113797. doi: 10.1016/j.ejmech.2021.113797. Epub 2021 Aug 28. Eur J Med Chem. 2021. PMID: 34520957

10

Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.

Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinović J, Kany AM, Haupenthal J, Köhnke J, Hartmann RW, Hirsch AKH. Kaya C, et al. Among authors: kany am. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112295. doi: 10.1002/anie.202112295. Epub 2021 Dec 13. Angew Chem Int Ed Engl. 2022. PMID: 34762767 Free PMC article.

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