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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function.
Palanikumar L, Karpauskaite L, Al-Sayegh M, Chehade I, Alam M, Hassan S, Maity D, Ali L, Kalmouni M, Hunashal Y, Ahmed J, Houhou T, Karapetyan S, Falls Z, Samudrala R, Pasricha R, Esposito G, Afzal AJ, Hamilton AD, Kumar S, Magzoub M. Palanikumar L, et al. Among authors: samudrala r. Nat Commun. 2021 Jun 25;12(1):3962. doi: 10.1038/s41467-021-23985-1. Nat Commun. 2021. PMID: 34172723 Free PMC article.
Shotgun drug repurposing biotechnology to tackle epidemics and pandemics.
Mangione W, Falls Z, Melendy T, Chopra G, Samudrala R. Mangione W, et al. Among authors: samudrala r. Drug Discov Today. 2020 Jul;25(7):1126-1128. doi: 10.1016/j.drudis.2020.05.002. Epub 2020 May 13. Drug Discov Today. 2020. PMID: 32405249 Free PMC article. No abstract available.
Association of C>U RNA Editing with Human Disease Variants.
Mandloi S, Falls Z, Deng R, Samudrala R, Elkin PL. Mandloi S, et al. Among authors: samudrala r. Stud Health Technol Inform. 2020 Jun 16;270:1205-1206. doi: 10.3233/SHTI200364. Stud Health Technol Inform. 2020. PMID: 32570581 Free PMC article.
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL. Chatrikhi R, et al. Among authors: samudrala r. Cell Chem Biol. 2021 Aug 19;28(8):1145-1157.e6. doi: 10.1016/j.chembiol.2021.02.007. Epub 2021 Mar 8. Cell Chem Biol. 2021. PMID: 33689684 Free PMC article.
Evaluating the performance of drug-repurposing technologies.
Schuler J, Falls Z, Mangione W, Hudson ML, Bruggemann L, Samudrala R. Schuler J, et al. Among authors: samudrala r. Drug Discov Today. 2022 Jan;27(1):49-64. doi: 10.1016/j.drudis.2021.08.002. Epub 2021 Aug 13. Drug Discov Today. 2022. PMID: 34400352 Free PMC article. Review.
A Deep-Learning Proteomic-Scale Approach for Drug Design.
Overhoff B, Falls Z, Mangione W, Samudrala R. Overhoff B, et al. Among authors: samudrala r. Pharmaceuticals (Basel). 2021 Dec 7;14(12):1277. doi: 10.3390/ph14121277. Pharmaceuticals (Basel). 2021. PMID: 34959678 Free PMC article.
147 results