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Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
Duval C, Baranauskas A, Feller T, Ali M, Cheah LT, Yuldasheva NY, Baker SR, McPherson HR, Raslan Z, Bailey MA, Cubbon RM, Connell SD, Ajjan RA, Philippou H, Naseem KM, Ridger VC, Ariëns RAS. Duval C, et al. Among authors: baker sr. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2103226118. doi: 10.1073/pnas.2103226118. Proc Natl Acad Sci U S A. 2021. PMID: 34183396 Free PMC article.
A fibrin biofilm covers blood clots and protects from microbial invasion.
Macrae FL, Duval C, Papareddy P, Baker SR, Yuldasheva N, Kearney KJ, McPherson HR, Asquith N, Konings J, Casini A, Degen JL, Connell SD, Philippou H, Wolberg AS, Herwald H, Ariëns RA. Macrae FL, et al. Among authors: baker sr. J Clin Invest. 2018 Aug 1;128(8):3356-3368. doi: 10.1172/JCI98734. Epub 2018 Jun 25. J Clin Invest. 2018. PMID: 29723163 Free PMC article.
Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab.
Macrae FL, Peacock-Young B, Bowman P, Baker SR, Quested S, Linton E, Hillmen P, Griffin M, Munir T, Payne D, McKinley C, Clarke D, Newton DJ, Hill A, Ariëns RAS. Macrae FL, et al. Among authors: baker sr. Am J Hematol. 2020 Aug;95(8):944-952. doi: 10.1002/ajh.25841. Epub 2020 May 11. Am J Hematol. 2020. PMID: 32311169 Free article.
529 results