Huang YF - Search Results

1

Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome.

Guiblet WM, DeGiorgio M, Cheng X, Chiaromonte F, Eckert KA, Huang YF, Makova KD. Guiblet WM, et al. Among authors: huang yf. Genome Res. 2021 Jul;31(7):1136-1149. doi: 10.1101/gr.269589.120. Epub 2021 Jun 29. Genome Res. 2021. PMID: 34187812 Free PMC article.

2

Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.

Guiblet WM, Cremona MA, Harris RS, Chen D, Eckert KA, Chiaromonte F, Huang YF, Makova KD. Guiblet WM, et al. Among authors: huang yf. Nucleic Acids Res. 2021 Feb 22;49(3):1497-1516. doi: 10.1093/nar/gkaa1269. Nucleic Acids Res. 2021. PMID: 33450015 Free PMC article.

3

Accurate sequencing of DNA motifs able to form alternative (non-B) structures.

Weissensteiner MH, Cremona MA, Guiblet WM, Stoler N, Harris RS, Cechova M, Eckert KA, Chiaromonte F, Huang YF, Makova KD. Weissensteiner MH, et al. Among authors: huang yf. Genome Res. 2023 Jun;33(6):907-922. doi: 10.1101/gr.277490.122. Epub 2023 Jul 11. Genome Res. 2023. PMID: 37433640 Free PMC article.

4

Assessing the Presence of Recent Adaptation in the Human Genome With Mixture Density Regression.

Salazar-Tortosa DF, Huang YF, Enard D. Salazar-Tortosa DF, et al. Among authors: huang yf. Genome Biol Evol. 2023 Oct 6;15(10):evad170. doi: 10.1093/gbe/evad170. Genome Biol Evol. 2023. PMID: 37713622 Free PMC article.

5

Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol.

Dukler N, Booth GT, Huang YF, Tippens N, Waters CT, Danko CG, Lis JT, Siepel A. Dukler N, et al. Among authors: huang yf. Genome Res. 2017 Nov;27(11):1816-1829. doi: 10.1101/gr.222935.117. Epub 2017 Oct 12. Genome Res. 2017. PMID: 29025894 Free PMC article.

6

Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease.

Huang YF, Siepel A. Huang YF, et al. Genome Res. 2019 Aug;29(8):1310-1321. doi: 10.1101/gr.245522.118. Epub 2019 Jun 27. Genome Res. 2019. PMID: 31249063 Free PMC article.

7

Extreme purifying selection against point mutations in the human genome.

Dukler N, Mughal MR, Ramani R, Huang YF, Siepel A. Dukler N, et al. Among authors: huang yf. Nat Commun. 2022 Jul 25;13(1):4312. doi: 10.1038/s41467-022-31872-6. Nat Commun. 2022. PMID: 35879308 Free PMC article.

8

Dissecting Genomic Determinants of Positive Selection with an Evolution-Guided Regression Model.

Huang YF. Huang YF. Mol Biol Evol. 2022 Jan 7;39(1):msab291. doi: 10.1093/molbev/msab291. Mol Biol Evol. 2022. PMID: 34597406 Free PMC article.

9

Unified inference of missense variant effects and gene constraints in the human genome.

Huang YF. Huang YF. PLoS Genet. 2020 Jul 15;16(7):e1008922. doi: 10.1371/journal.pgen.1008922. eCollection 2020 Jul. PLoS Genet. 2020. PMID: 32667917 Free PMC article.

10

Transcription factor binding sites are frequently under accelerated evolution in primates.

Zhang X, Fang B, Huang YF. Zhang X, et al. Among authors: huang yf. Nat Commun. 2023 Feb 11;14(1):783. doi: 10.1038/s41467-023-36421-3. Nat Commun. 2023. PMID: 36774380 Free PMC article.

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