Heallen TR - Search Results

1

Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction.

Liu S, Li K, Wagner Florencio L, Tang L, Heallen TR, Leach JP, Wang Y, Grisanti F, Willerson JT, Perin EC, Zhang S, Martin JF. Liu S, et al. Among authors: heallen tr. Sci Transl Med. 2021 Jun 30;13(600):eabd6892. doi: 10.1126/scitranslmed.abd6892. Sci Transl Med. 2021. PMID: 34193613 Free PMC article.

2

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.

Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF. Heallen T, et al. Science. 2011 Apr 22;332(6028):458-61. doi: 10.1126/science.1199010. Science. 2011. PMID: 21512031 Free PMC article.

3

Hippo signaling impedes adult heart regeneration.

Heallen T, Morikawa Y, Leach J, Tao G, Willerson JT, Johnson RL, Martin JF. Heallen T, et al. Development. 2013 Dec;140(23):4683-90. doi: 10.1242/dev.102798. Development. 2013. PMID: 24255096 Free PMC article.

4

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties.

Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Song S, et al. Among authors: heallen tr. Cancer Res. 2014 Aug 1;74(15):4170-82. doi: 10.1158/0008-5472.CAN-13-3569. Epub 2014 Jun 6. Cancer Res. 2014. PMID: 24906622 Free PMC article.

5

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice.

Morikawa Y, Zhang M, Heallen T, Leach J, Tao G, Xiao Y, Bai Y, Li W, Willerson JT, Martin JF. Morikawa Y, et al. Sci Signal. 2015 May 5;8(375):ra41. doi: 10.1126/scisignal.2005781. Sci Signal. 2015. PMID: 25943351 Free PMC article.

6

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury.

Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin JF. Tao G, et al. Among authors: heallen tr. Nature. 2016 Jun 2;534(7605):119-23. doi: 10.1038/nature17959. Epub 2016 May 25. Nature. 2016. PMID: 27251288 Free PMC article.

7

Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.

Morikawa Y, Heallen T, Leach J, Xiao Y, Martin JF. Morikawa Y, et al. Nature. 2017 Jul 13;547(7662):227-231. doi: 10.1038/nature22979. Epub 2017 Jun 5. Nature. 2017. PMID: 28581498 Free PMC article.

8

Hippo pathway deficiency reverses systolic heart failure after infarction.

Leach JP, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill MC, Segura A, Willerson JT, Martin JF. Leach JP, et al. Nature. 2017 Oct 12;550(7675):260-264. doi: 10.1038/nature24045. Epub 2017 Oct 4. Nature. 2017. PMID: 28976966 Free PMC article.

9

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration.

Wang J, Liu S, Heallen T, Martin JF. Wang J, et al. Nat Rev Cardiol. 2018 Nov;15(11):672-684. doi: 10.1038/s41569-018-0063-3. Nat Rev Cardiol. 2018. PMID: 30111784 Review.

10

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo.

Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF. Monroe TO, et al. Dev Cell. 2019 Mar 25;48(6):765-779.e7. doi: 10.1016/j.devcel.2019.01.017. Epub 2019 Feb 14. Dev Cell. 2019. PMID: 30773489 Free PMC article.

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