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Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM].
Davis AG, Wasserman S, Maxebengula M, Stek C, Bremer M, Daroowala R, Aziz S, Goliath R, Stegmann S, Koekemoer S, Jackson A, Lai Sai L, Kadernani Y, Sihoyiya T, Liang CJ, Dodd L, Denti P, Crede T, Naude J, Szymanski P, Vallie Y, Banderker I, Moosa S, Raubenheimer P, Lai RPJ, Joska J, Nightingale S, Dreyer A, Wahl G, Offiah C, Vorster I, Candy S, Robertson F, Meintjes E, Maartens G, Black J, Meintjes G, Wilkinson RJ. Davis AG, et al. Among authors: daroowala r. Wellcome Open Res. 2021 Jun 1;6:136. doi: 10.12688/wellcomeopenres.16783.1. eCollection 2021. Wellcome Open Res. 2021. PMID: 34286103 Free PMC article.
Plasma Pharmacokinetics of High-Dose Oral versus Intravenous Rifampicin in Patients with Tuberculous Meningitis: a Randomized Controlled Trial.
Wasserman S, Davis A, Stek C, Chirehwa M, Botha S, Daroowala R, Bremer M, Maxebengula M, Koekemoer S, Goliath R, Jackson A, Crede T, Naude J, Szymanski P, Vallie Y, Moosa MS, Wiesner L, Black J, Meintjes G, Maartens G, Wilkinson RJ. Wasserman S, et al. Among authors: daroowala r. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0014021. doi: 10.1128/AAC.00140-21. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 33972248 Free PMC article. Clinical Trial.
Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection.
Riou C, du Bruyn E, Stek C, Daroowala R, Goliath RT, Abrahams F, Said-Hartley Q, Allwood BW, Hsiao NY, Wilkinson KA, Arlehamn CSL, Sette A, Wasserman S, Wilkinson RJ; HIATUS consortium. Riou C, et al. Among authors: daroowala r. J Clin Invest. 2021 Jun 15;131(12):e149125. doi: 10.1172/JCI149125. J Clin Invest. 2021. PMID: 33945513 Free PMC article. Clinical Trial.
Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa.
Western Cape Department of Health in collaboration with the National Institute for Communicable Diseases, South Africa. Western Cape Department of Health in collaboration with the National Institute for Communicable Diseases, South Africa. Clin Infect Dis. 2021 Oct 5;73(7):e2005-e2015. doi: 10.1093/cid/ciaa1198. Clin Infect Dis. 2021. PMID: 32860699 Free PMC article.
High resolution imaging and five-year tuberculosis contact outcomes.
Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR Jr, Salgame P, Alland D, Barry CE 3rd, Flynn JL, Ellner JJ, Wilkinson RJ. Esmail H, et al. Among authors: daroowala r. medRxiv [Preprint]. 2023 Jul 3:2023.07.03.23292111. doi: 10.1101/2023.07.03.23292111. medRxiv. 2023. PMID: 37461515 Free PMC article. Preprint.
Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa.
du Bruyn E, Stek C, Daroowala R, Said-Hartley Q, Hsiao M, Schafer G, Goliath RT, Abrahams F, Jackson A, Wasserman S, Allwood BW, Davis AG, Lai RP, Coussens AK, Wilkinson KA, de Vries J, Tiffin N, Cerrone M, Ntusi NAB; HIATUS consortium; Riou C, Wilkinson RJ. du Bruyn E, et al. Among authors: daroowala r. Nat Commun. 2023 Jan 12;14(1):188. doi: 10.1038/s41467-022-35689-1. Nat Commun. 2023. PMID: 36635274 Free PMC article.
A Phase 2A Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid, With or Without Aspirin, for Human Immunodeficiency Virus-Associated Tuberculous Meningitis: The LASER-TBM Trial.
Davis AG, Wasserman S, Stek C, Maxebengula M, Jason Liang C, Stegmann S, Koekemoer S, Jackson A, Kadernani Y, Bremer M, Daroowala R, Aziz S, Goliath R, Lai Sai L, Sihoyiya T, Denti P, Lai RPJ, Crede T, Naude J, Szymanski P, Vallie Y, Banderker IA, Moosa MS, Raubenheimer P, Candy S, Offiah C, Wahl G, Vorster I, Maartens G, Black J, Meintjes G, Wilkinson RJ. Davis AG, et al. Among authors: daroowala r. Clin Infect Dis. 2023 Apr 17;76(8):1412-1422. doi: 10.1093/cid/ciac932. Clin Infect Dis. 2023. PMID: 36482216 Free PMC article. Clinical Trial.