Chibale K - Search Results

1

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.

Newman H, Krajnc A, Bellini D, Eyermann CJ, Boyle GA, Paterson NG, McAuley KE, Lesniak R, Gangar M, von Delft F, Brem J, Chibale K, Schofield CJ, Dowson CG. Newman H, et al. Among authors: chibale k. J Med Chem. 2021 Aug 12;64(15):11379-11394. doi: 10.1021/acs.jmedchem.1c00717. Epub 2021 Jul 31. J Med Chem. 2021. PMID: 34337941 Free PMC article.

2

The synthesis of parasitic cysteine protease and trypanothione reductase inhibitors.

Chibale K, Musonda CC. Chibale K, et al. Curr Med Chem. 2003 Sep;10(18):1863-89. doi: 10.2174/0929867033456963. Curr Med Chem. 2003. PMID: 12871109 Review.

3

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3901-5. doi: 10.1016/j.bmcl.2004.05.063. Bioorg Med Chem Lett. 2004. PMID: 15225694

4

Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery.

Musonda CC, Chibale K. Musonda CC, et al. Among authors: chibale k. Curr Med Chem. 2004 Oct;11(19):2519-33. doi: 10.2174/0929867043364469. Curr Med Chem. 2004. PMID: 15544460 Review.

5

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Chiyanzu I, et al. Among authors: chibale k. Bioorg Med Chem. 2005 May 2;13(9):3249-61. doi: 10.1016/j.bmc.2005.02.037. Bioorg Med Chem. 2005. PMID: 15809160

6

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.

Chouteau F, Ramanitrahasimbola D, Rasoanaivo P, Chibale K. Chouteau F, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8. doi: 10.1016/j.bmcl.2005.04.033. Bioorg Med Chem Lett. 2005. PMID: 15908208

7

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.

Musonda CC, Gut J, Rosenthal PJ, Yardley V, Carvalho de Souza RC, Chibale K. Musonda CC, et al. Among authors: chibale k. Bioorg Med Chem. 2006 Aug 15;14(16):5605-15. doi: 10.1016/j.bmc.2006.04.035. Epub 2006 May 11. Bioorg Med Chem. 2006. PMID: 16690319

8

Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.

Nchinda AT, Chibale K, Redelinghuys P, Sturrock ED. Nchinda AT, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4616-9. doi: 10.1016/j.bmcl.2006.06.004. Epub 2006 Jun 19. Bioorg Med Chem Lett. 2006. PMID: 16784843

9

Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.

Nchinda AT, Chibale K, Redelinghuys P, Sturrock ED. Nchinda AT, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4612-5. doi: 10.1016/j.bmcl.2006.06.003. Epub 2006 Jun 19. Bioorg Med Chem Lett. 2006. PMID: 16784850

10

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.

Chipeleme A, Gut J, Rosenthal PJ, Chibale K. Chipeleme A, et al. Among authors: chibale k. Bioorg Med Chem. 2007 Jan 1;15(1):273-82. doi: 10.1016/j.bmc.2006.09.055. Epub 2006 Sep 29. Bioorg Med Chem. 2007. PMID: 17052908

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