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A topological switch in CFTR modulates channel activity and sensitivity to unfolding.
Scholl D, Sigoillot M, Overtus M, Martinez RC, Martens C, Wang Y, Pardon E, Laeremans T, Garcia-Pino A, Steyaert J, Sheppard DN, Hendrix J, Govaerts C. Scholl D, et al. Among authors: overtus m. Nat Chem Biol. 2021 Sep;17(9):989-997. doi: 10.1038/s41589-021-00844-0. Epub 2021 Aug 2. Nat Chem Biol. 2021. PMID: 34341587
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Sigoillot M, Overtus M, Grodecka M, Scholl D, Garcia-Pino A, Laeremans T, He L, Pardon E, Hildebrandt E, Urbatsch I, Steyaert J, Riordan JR, Govaerts C. Sigoillot M, et al. Among authors: overtus m. Nat Commun. 2019 Jun 14;10(1):2636. doi: 10.1038/s41467-019-10714-y. Nat Commun. 2019. PMID: 31201318 Free PMC article.