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Page 1
A topological switch in CFTR modulates channel activity and sensitivity to unfolding.
Scholl D, Sigoillot M, Overtus M, Martinez RC, Martens C, Wang Y, Pardon E, Laeremans T, Garcia-Pino A, Steyaert J, Sheppard DN, Hendrix J, Govaerts C. Scholl D, et al. Among authors: sheppard dn. Nat Chem Biol. 2021 Sep;17(9):989-997. doi: 10.1038/s41589-021-00844-0. Epub 2021 Aug 2. Nat Chem Biol. 2021. PMID: 34341587
The patch-clamp and planar lipid bilayer techniques: powerful and versatile tools to investigate the CFTR Cl- channel.
Sheppard DN, Gray MA, Gong X, Sohma Y, Kogan I, Benos DJ, Scott-Ward TS, Chen JH, Li H, Cai Z, Gupta J, Li C, Ramjeesingh M, Berdiev BK, Ismailov II, Bear CE, Hwang TC, Linsdell P, Hug MJ. Sheppard DN, et al. J Cyst Fibros. 2004 Aug;3 Suppl 2:101-8. doi: 10.1016/j.jcf.2004.05.046. J Cyst Fibros. 2004. PMID: 15463939 Free article. Review.
Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR.
Scott-Ward TS, Cai Z, Dawson ES, Doherty A, Da Paula AC, Davidson H, Porteous DJ, Wainwright BJ, Amaral MD, Sheppard DN, Boyd AC. Scott-Ward TS, et al. Among authors: sheppard dn. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16365-70. doi: 10.1073/pnas.0701562104. Epub 2007 Oct 3. Proc Natl Acad Sci U S A. 2007. PMID: 17913891 Free PMC article.
118 results