Chen S - Search Results

1

Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy.

Lyu C, Ye Y, Lensing MM, Wagner KU, Weigel RJ, Chen S. Lyu C, et al. Among authors: chen s. JCI Insight. 2021 Sep 22;6(18):e150532. doi: 10.1172/jci.insight.150532. JCI Insight. 2021. PMID: 34343132 Free PMC article.

2

A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer.

Tang X, Sun Z, Runne C, Madsen J, Domann F, Henry M, Lin F, Chen S. Tang X, et al. Among authors: chen s. J Biol Chem. 2011 Apr 15;286(15):13244-54. doi: 10.1074/jbc.M110.206615. Epub 2011 Feb 24. J Biol Chem. 2011. PMID: 21349837 Free PMC article.

3

Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.

Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ye Y, et al. Among authors: chen s. Cell Signal. 2014 Nov;26(11):2514-20. doi: 10.1016/j.cellsig.2014.07.030. Epub 2014 Aug 2. Cell Signal. 2014. PMID: 25093805 Free PMC article.

4

Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion.

Ye Y, Tang X, Sun Z, Chen S. Ye Y, et al. Among authors: chen s. Oncotarget. 2016 Apr 5;7(14):17854-69. doi: 10.18632/oncotarget.7439. Oncotarget. 2016. PMID: 26895380 Free PMC article.

5

Inhibiting G protein βγ signaling blocks prostate cancer progression and enhances the efficacy of paclitaxel.

Paudyal P, Xie Q, Vaddi PK, Henry MD, Chen S. Paudyal P, et al. Among authors: chen s. Oncotarget. 2017 May 30;8(22):36067-36081. doi: 10.18632/oncotarget.16428. Oncotarget. 2017. PMID: 28415604 Free PMC article.

6

Blocking Gi/o-Coupled Signaling Eradicates Cancer Stem Cells and Sensitizes Breast Tumors to HER2-Targeted Therapies to Inhibit Tumor Relapse.

Lyu C, Ye Y, Weigel RJ, Chen S. Lyu C, et al. Among authors: chen s. Cancers (Basel). 2022 Mar 28;14(7):1719. doi: 10.3390/cancers14071719. Cancers (Basel). 2022. PMID: 35406489 Free PMC article.

7

Active Gα_i/o Mutants Accelerate Breast Tumor Metastasis via the c-Src Pathway.

Lyu C, Bhimani AK, Draus WT, Weigel R, Chen S. Lyu C, et al. Among authors: chen s. Mol Cell Biol. 2023;43(12):650-663. doi: 10.1080/10985549.2023.2285833. Epub 2023 Dec 20. Mol Cell Biol. 2023. PMID: 38099640

8

Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development.

Lyu C, Vaddi PK, Elshafae S, Pradeep A, Ma D, Chen S. Lyu C, et al. Among authors: chen s. Oncogene. 2024 Nov 13. doi: 10.1038/s41388-024-03224-9. Online ahead of print. Oncogene. 2024. PMID: 39537875

9

Elimination of SOX2/OCT4-Associated Prostate Cancer Stem Cells Blocks Tumor Development and Enhances Therapeutic Response.

Vaddi PK, Stamnes MA, Cao H, Chen S. Vaddi PK, et al. Among authors: chen s. Cancers (Basel). 2019 Sep 8;11(9):1331. doi: 10.3390/cancers11091331. Cancers (Basel). 2019. PMID: 31500347 Free PMC article.

10

The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis.

Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE. Muniz VP, et al. Among authors: chen s. Mol Cancer Res. 2011 Jul;9(7):867-77. doi: 10.1158/1541-7786.MCR-10-0475. Epub 2011 Jun 2. Mol Cancer Res. 2011. PMID: 21636682 Free PMC article.

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