Griffin PR - Search Results

1

Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).

Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D. Li K, et al. Among authors: griffin pr. Nucleic Acids Res. 2021 Sep 27;49(17):9978-9991. doi: 10.1093/nar/gkab712. Nucleic Acids Res. 2021. PMID: 34403472 Free PMC article.

2

Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.

de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, Brust R, Munoz-Tello P, Gardner WJ Jr, Marciano DP, Kong X, Griffin PR, Kojetin DJ. de Vera IMS, et al. Among authors: griffin pr. Structure. 2017 Oct 3;25(10):1506-1518.e4. doi: 10.1016/j.str.2017.07.019. Epub 2017 Sep 7. Structure. 2017. PMID: 28890360 Free PMC article.

3

SPA70 is a potent antagonist of human pregnane X receptor.

Lin W, Wang YM, Chai SC, Lv L, Zheng J, Wu J, Zhang Q, Wang YD, Griffin PR, Chen T. Lin W, et al. Among authors: griffin pr. Nat Commun. 2017 Sep 29;8(1):741. doi: 10.1038/s41467-017-00780-5. Nat Commun. 2017. PMID: 28963450 Free PMC article.

4

Unique Interactome Network Signatures for Peroxisome Proliferator-activated Receptor Gamma (PPARγ) Modulation by Functional Selective Ligands.

Lam VQ, Zheng J, Griffin PR. Lam VQ, et al. Among authors: griffin pr. Mol Cell Proteomics. 2017 Dec;16(12):2098-2110. doi: 10.1074/mcp.RA117.000308. Epub 2017 Sep 29. Mol Cell Proteomics. 2017. PMID: 28972081 Free PMC article.

5

CINPA1 binds directly to constitutive androstane receptor and inhibits its activity.

Cherian MT, Chai SC, Wright WC, Singh A, Alexandra Casal M, Zheng J, Wu J, Lee RE, Griffin PR, Chen T. Cherian MT, et al. Among authors: griffin pr. Biochem Pharmacol. 2018 Jun;152:211-223. doi: 10.1016/j.bcp.2018.03.029. Epub 2018 Mar 31. Biochem Pharmacol. 2018. PMID: 29608908 Free PMC article.

6

Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.

Chinthalapudi K, Mandati V, Zheng J, Sharff AJ, Bricogne G, Griffin PR, Kissil J, Izard T. Chinthalapudi K, et al. Among authors: griffin pr. Nat Commun. 2018 Apr 6;9(1):1338. doi: 10.1038/s41467-018-03648-4. Nat Commun. 2018. PMID: 29626191 Free PMC article.

7

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.

Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR. Zheng J, et al. Among authors: griffin pr. Structure. 2018 Nov 6;26(11):1431-1439.e6. doi: 10.1016/j.str.2018.07.007. Epub 2018 Aug 23. Structure. 2018. PMID: 30146169 Free PMC article.

8

Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1.

de Vera IMS, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, Hughes TS, Rance M, Griffin PR, Kojetin DJ. de Vera IMS, et al. Among authors: griffin pr. Structure. 2019 Jan 2;27(1):66-77.e5. doi: 10.1016/j.str.2018.10.002. Epub 2018 Nov 8. Structure. 2019. PMID: 30416039 Free PMC article.

9

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.

Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR. Zheng J, et al. Among authors: griffin pr. Nat Commun. 2018 Dec 18;9(1):5366. doi: 10.1038/s41467-018-07780-z. Nat Commun. 2018. PMID: 30560918 Free PMC article.

10

Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone.

Mosure SA, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S, Kojetin DJ. Mosure SA, et al. Among authors: griffin pr. J Med Chem. 2019 Feb 28;62(4):2008-2023. doi: 10.1021/acs.jmedchem.8b01573. Epub 2019 Feb 7. J Med Chem. 2019. PMID: 30676741 Free PMC article.

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