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Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing.
Nishimura E, Pridal L, Glendorf T, Hansen BF, Hubálek F, Kjeldsen T, Kristensen NR, Lützen A, Lyby K, Madsen P, Pedersen TÅ, Ribel-Madsen R, Stidsen CE, Haahr H. Nishimura E, et al. Among authors: pedersen ta. BMJ Open Diabetes Res Care. 2021 Aug;9(1):e002301. doi: 10.1136/bmjdrc-2021-002301. BMJ Open Diabetes Res Care. 2021. PMID: 34413118 Free PMC article. Clinical Trial.
Structure, Aggregation, and Activity of a Covalent Insulin Dimer Formed During Storage of Neutral Formulation of Human Insulin.
Hjorth CF, Norrman M, Wahlund PO, Benie AJ, Petersen BO, Jessen CM, Pedersen TÅ, Vestergaard K, Steensgaard DB, Pedersen JS, Naver H, Hubálek F, Poulsen C, Otzen D. Hjorth CF, et al. Among authors: pedersen ta, pedersen js. J Pharm Sci. 2016 Apr;105(4):1376-86. doi: 10.1016/j.xphs.2016.01.003. Epub 2016 Feb 23. J Pharm Sci. 2016. PMID: 26921119
Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates.
Tagmose TM, Pedersen KM, Pridal L, Stidsen CE, Pedersen MØ, Lin Z, Zhang Y, Wan Z, Ferreras M, Naver H, Nielsen PK, Cao Z, Wang Y, Lykke L, Christensen JL, Jensen VS, Manfè V, Pedersen TÅ, Johansson E, Madsen P, Kodra JT, Münzel M, De Maria L, Nishimura E, Kjeldsen TB. Tagmose TM, et al. Among authors: pedersen ta. J Med Chem. 2022 Feb 10;65(3):2633-2645. doi: 10.1021/acs.jmedchem.1c02039. Epub 2022 Feb 1. J Med Chem. 2022. PMID: 35104142
Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models.
Hvid H, Brand CL, Hummelshøj T, Jensen S, Bouman SD, Bowler A, Poulsen BR, Tiainen P, Åkertröm T, Demozay D, Hoeg-Jensen T, Ingvorsen C, Pedersen TÅ, McGuire J, Egebjerg T, Cappelen KA, Eliasen IP, Hansen BF, Hennen S, Stidsen CE, Olsen GS, Roed NK. Hvid H, et al. Among authors: pedersen ta. Diabetologia. 2023 Feb;66(2):376-389. doi: 10.1007/s00125-022-05828-w. Epub 2022 Nov 21. Diabetologia. 2023. PMID: 36404376 Free PMC article.
Glucose-sensitive insulin with attenuation of hypoglycaemia.
Hoeg-Jensen T, Kruse T, Brand CL, Sturis J, Fledelius C, Nielsen PK, Nishimura E, Madsen AR, Lykke L, Halskov KS, Koščová S, Kotek V, Davis AP, Tromans RA, Tomsett M, Peñuelas-Haro G, Leonard DJ, Orchard MG, Chapman A, Invernizzi G, Johansson E, Granata D, Hansen BF, Pedersen TA, Kildegaard J, Pedersen KM, Refsgaard HHF, Alifrangis L, Fels JJ, Neutzsky-Wulff AV, Sauerberg P, Slaaby R. Hoeg-Jensen T, et al. Among authors: pedersen ta. Nature. 2024 Oct;634(8035):944-951. doi: 10.1038/s41586-024-08042-3. Epub 2024 Oct 16. Nature. 2024. PMID: 39415004 Free PMC article.
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