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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.
Khonde LP, Müller R, Boyle GA, Reddy V, Nchinda AT, Eyermann CJ, Fienberg S, Singh V, Myrick A, Abay E, Njoroge M, Lawrence N, Su Q, Myers TG, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden PD, Massoudi LM, Robertson GT, Lenaerts AJ, Basarab GS, Ghorpade SR, Chibale K. Khonde LP, et al. Among authors: lenaerts aj. J Med Chem. 2021 Sep 9;64(17):12790-12807. doi: 10.1021/acs.jmedchem.1c00837. Epub 2021 Aug 20. J Med Chem. 2021. PMID: 34414766 Free PMC article.
A 33-year-old man with jaundice, dyspnoea and fever.
Van Haren M, Lenaerts A, Paridaens H, Machiels P. Van Haren M, et al. Clin Res Hepatol Gastroenterol. 2019 Feb;43(1):104-107. doi: 10.1016/j.clinre.2018.11.007. Epub 2018 Dec 14. Clin Res Hepatol Gastroenterol. 2019. PMID: 30559031 No abstract available.
Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors.
Boyne ME, Sullivan TJ, amEnde CW, Lu H, Gruppo V, Heaslip D, Amin AG, Chatterjee D, Lenaerts A, Tonge PJ, Slayden RA. Boyne ME, et al. Antimicrob Agents Chemother. 2007 Oct;51(10):3562-7. doi: 10.1128/AAC.00383-07. Epub 2007 Jul 30. Antimicrob Agents Chemother. 2007. PMID: 17664324 Free PMC article.
Discovery of novel isoxazolines as anti-tuberculosis agents.
Tangallapally RP, Sun D, Rakesh, Budha N, Lee RE, Lenaerts AJ, Meibohm B, Lee RE. Tangallapally RP, et al. Among authors: lenaerts aj. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6638-42. doi: 10.1016/j.bmcl.2007.09.048. Epub 2007 Sep 15. Bioorg Med Chem Lett. 2007. PMID: 17937983 Free PMC article.
114 results