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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Temps C, Lietha D, Webb ER, Li XF, Dawson JC, Muir M, Macleod KG, Valero T, Munro AF, Contreras-Montoya R, Luque-Ortega JR, Fraser C, Beetham H, Schoenherr C, Lopalco M, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. Temps C, et al. Among authors: macleod kg. Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613. Epub 2021 Aug 20. Cancer Res. 2021. PMID: 34417202 Free PMC article.
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.
Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C. Girotti MR, et al. Cancer Cell. 2015 Jan 12;27(1):85-96. doi: 10.1016/j.ccell.2014.11.006. Epub 2014 Dec 11. Cancer Cell. 2015. PMID: 25500121 Free PMC article.
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.
Creedon H, Gómez-Cuadrado L, Tarnauskaitė Ž, Balla J, Canel M, MacLeod KG, Serrels B, Fraser C, Unciti-Broceta A, Tracey N, Le Bihan T, Klinowska T, Sims AH, Byron A, Brunton VG. Creedon H, et al. Among authors: macleod kg. Oncotarget. 2016 Mar 8;7(10):11539-52. doi: 10.18632/oncotarget.7317. Oncotarget. 2016. PMID: 26883193 Free PMC article.
Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array.
Partolina M, Thoms HC, MacLeod KG, Rodriguez-Blanco G, Clarke MN, Venkatasubramani AV, Beesoo R, Larionov V, Neergheen-Bhujun VS, Serrels B, Kimura H, Carragher NO, Kagansky A. Partolina M, et al. Among authors: macleod kg. Cell Death Discov. 2017 Mar 6;3:16077. doi: 10.1038/cddiscovery.2016.77. eCollection 2017. Cell Death Discov. 2017. PMID: 28326191 Free PMC article.
Reverse Phase Protein Arrays and Drug Discovery.
Macleod KG, Serrels B, Carragher NO. Macleod KG, et al. Methods Mol Biol. 2017;1647:153-169. doi: 10.1007/978-1-4939-7201-2_10. Methods Mol Biol. 2017. PMID: 28809001
N-cadherin stabilises neural identity by dampening anti-neural signals.
Punovuori K, Migueles RP, Malaguti M, Blin G, Macleod KG, Carragher NO, Pieters T, van Roy F, Stemmler MP, Lowell S. Punovuori K, et al. Among authors: macleod kg. Development. 2019 Nov 8;146(21):dev183269. doi: 10.1242/dev.183269. Development. 2019. PMID: 31601548 Free PMC article.
67 results