Mahawaththa MC - Search Results

1

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.

Ullrich S, Sasi VM, Mahawaththa MC, Ekanayake KB, Morewood R, George J, Shuttleworth L, Zhang X, Whitefield C, Otting G, Jackson C, Nitsche C. Ullrich S, et al. Among authors: mahawaththa mc. Bioorg Med Chem Lett. 2021 Oct 15;50:128333. doi: 10.1016/j.bmcl.2021.128333. Epub 2021 Aug 19. Bioorg Med Chem Lett. 2021. PMID: 34418570 Free PMC article.

2

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease.

Mahawaththa MC, Pearce BJG, Szabo M, Graham B, Klein CD, Nitsche C, Otting G. Mahawaththa MC, et al. Antiviral Res. 2017 Jun;142:141-147. doi: 10.1016/j.antiviral.2017.03.011. Epub 2017 Mar 21. Antiviral Res. 2017. PMID: 28336347

3

Site-selective tagging of proteins by pnictogen-mediated self-assembly.

Nitsche C, Mahawaththa MC, Becker W, Huber T, Otting G. Nitsche C, et al. Among authors: mahawaththa mc. Chem Commun (Camb). 2017 Oct 3;53(79):10894-10897. doi: 10.1039/c7cc06155b. Chem Commun (Camb). 2017. PMID: 28890978

4

Small neutral Gd(iii) tags for distance measurements in proteins by double electron-electron resonance experiments.

Mahawaththa MC , Lee MD , Giannoulis A , Adams LA , Feintuch A , Swarbrick JD , Graham B , Nitsche C , Goldfarb D , Otting G . Mahawaththa MC , et al. Phys Chem Chem Phys. 2018 Sep 19;20(36):23535-23545. doi: 10.1039/c8cp03532f. Phys Chem Chem Phys. 2018. PMID: 30183028

5

De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease.

Nitsche C, Passioura T, Varava P, Mahawaththa MC, Leuthold MM, Klein CD, Suga H, Otting G. Nitsche C, et al. Among authors: mahawaththa mc. ACS Med Chem Lett. 2019 Jan 4;10(2):168-174. doi: 10.1021/acsmedchemlett.8b00535. eCollection 2019 Feb 14. ACS Med Chem Lett. 2019. PMID: 30783498 Free PMC article.

6

Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions.

Qianzhu H, Welegedara AP, Williamson H, McGrath AE, Mahawaththa MC, Dixon NE, Otting G, Huber T. Qianzhu H, et al. Among authors: mahawaththa mc. J Am Chem Soc. 2020 Oct 14;142(41):17277-17281. doi: 10.1021/jacs.0c07976. Epub 2020 Sep 30. J Am Chem Soc. 2020. PMID: 32975937

7

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme.

Kaczmarski JA, Mahawaththa MC, Feintuch A, Clifton BE, Adams LA, Goldfarb D, Otting G, Jackson CJ. Kaczmarski JA, et al. Among authors: mahawaththa mc. Nat Commun. 2020 Nov 23;11(1):5945. doi: 10.1038/s41467-020-19695-9. Nat Commun. 2020. PMID: 33230119 Free PMC article.

8

Cell-Free Synthesis of Selenoproteins in High Yield and Purity for Selective Protein Tagging.

Welegedara AP, Maleckis A, Bandara R, Mahawaththa MC, Dilhani Herath I, Jiun Tan Y, Giannoulis A, Goldfarb D, Otting G, Huber T. Welegedara AP, et al. Among authors: mahawaththa mc. Chembiochem. 2021 Apr 16;22(8):1480-1486. doi: 10.1002/cbic.202000785. Epub 2021 Jan 28. Chembiochem. 2021. PMID: 33319405

9

Organoarsenic probes to study proteins by NMR spectroscopy.

Mahawaththa MC, Orton HW, Adekoya I, Huber T, Otting G, Nitsche C. Mahawaththa MC, et al. Chem Commun (Camb). 2022 Jan 13;58(5):701-704. doi: 10.1039/d1cc06497e. Chem Commun (Camb). 2022. PMID: 34927186

10

Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.

Johansen-Leete J, Ullrich S, Fry SE, Frkic R, Bedding MJ, Aggarwal A, Ashhurst AS, Ekanayake KB, Mahawaththa MC, Sasi VM, Luedtke S, Ford DJ, O'Donoghue AJ, Passioura T, Larance M, Otting G, Turville S, Jackson CJ, Nitsche C, Payne RJ. Johansen-Leete J, et al. Among authors: mahawaththa mc. Chem Sci. 2022 Feb 28;13(13):3826-3836. doi: 10.1039/d1sc06750h. eCollection 2022 Mar 30. Chem Sci. 2022. PMID: 35432913 Free PMC article.

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